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CAS

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120851-71-0

Trans-1-Benzoyl-4-phenyl-L-proline is a chemical compound that belongs to the class of organic compounds known as L-alpha-amino acids. These are proteinogenic amino acids which have the L-configuration of the alpha-carbon atom. trans-1-Benzoyl-4-phenyl-L-proline is most notably known for its role in the synthesis of drugs, particularly angiotensin-converting enzyme (ACE) inhibitors. ACE inhibitors are most commonly used to treat high blood pressure and heart failure. Trans-1-Benzoyl-4-phenyl-L-proline exhibits a molecular weight of 325.36 g/mol and can be indicated through the molecular formula C19H17NO3. The structural appearance of the compound is defined by the presence of a benzoyl group, a phenyl group, and a proline residue.

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  • 120851-71-0 Structure

  • Basic information

    1. Product Name: trans-1-Benzoyl-4-phenyl-L-proline
    2. Synonyms: TRANS-1-BENZOYL-4-PHENYL-L-PROLINE (INTERMEDIATE OF FOSINOPRIL );trans-1-Benzoyl-4-phenyl-L-proline;trans-1-Benzoyl-4-ph;trans-1-Benzoyl-4-phenylpyrrolidine-2-carboxylic acid
    3. CAS NO:120851-71-0
    4. Molecular Formula: C18H17NO3
    5. Molecular Weight: 295.33
    6. EINECS: 1592732-453-0
    7. Product Categories: API intermediates
    8. Mol File: 120851-71-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 518.142 °C at 760 mmHg
    3. Flash Point: 267.163 °C
    4. Appearance: /
    5. Density: 1.266 g/cm3
    6. Refractive Index: 1.622
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: trans-1-Benzoyl-4-phenyl-L-proline(CAS DataBase Reference)
    10. NIST Chemistry Reference: trans-1-Benzoyl-4-phenyl-L-proline(120851-71-0)
    11. EPA Substance Registry System: trans-1-Benzoyl-4-phenyl-L-proline(120851-71-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 120851-71-0(Hazardous Substances Data)

120851-71-0 Usage

Uses

Used in Pharmaceutical Industry:
Trans-1-Benzoyl-4-phenyl-L-proline is used as a key intermediate in the synthesis of drugs, particularly angiotensin-converting enzyme (ACE) inhibitors. These ACE inhibitors are crucial in the treatment of high blood pressure and heart failure, as they help regulate blood pressure and improve heart function.
Used in Drug Synthesis:
Trans-1-Benzoyl-4-phenyl-L-proline is used as a building block in the development of new pharmaceutical compounds. Its unique structure, which includes a benzoyl group, a phenyl group, and a proline residue, allows for the creation of various drug molecules with potential therapeutic applications. This makes it a valuable component in the field of medicinal chemistry and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 120851-71-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,8,5 and 1 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 120851-71:
(8*1)+(7*2)+(6*0)+(5*8)+(4*5)+(3*1)+(2*7)+(1*1)=100
100 % 10 = 0
So 120851-71-0 is a valid CAS Registry Number.
InChI:InChI=1/C18H17NO3/c20-17(14-9-5-2-6-10-14)19-12-15(11-16(19)18(21)22)13-7-3-1-4-8-13/h1-10,15-16H,11-12H2,(H,21,22)/t15?,16-/m0/s1

120851-71-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name trans-1-Benzoyl-4-phenyl-L-proline

1.2 Other means of identification

Product number -
Other names trans-1-Benzoyl-4-ph

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:120851-71-0 SDS

120851-71-0Relevant articles and documents

Preparation methods of antihypertensive Fosinopril sodium and key intermediate thereof

-

Paragraph 0014, (2017/12/14)

The invention relates to preparation methods of an antihypertensive Fosinopril sodium and a key intermediate thereof trans-4-phenyl-L-proline suitable for industrial production. Synthesis of the key intermediate trans-4-phenyl-L-proline has high chiral selectivity, and the method is simple and easy to operate.

Stereospecific Friedel-Crafts alkylation of benzene with 4-mesyloxy-L-prolines. A new synthesis of 4-phenylprolines

Kronenthal,Mueller,Kuester,Kissick,Johnson

, p. 1241 - 1244 (2007/10/02)

The reaction of benzene with cis- and trans-N-benzoyl-4-mesyloxy-L-proline (11 and 12) in the presence of AlCl3 stereospecifically produces the corresponding trans- and cis-4-phenylproline derivatives.

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