Welcome to LookChem.com Sign In|Join Free

Cas Database

121-52-8

121-52-8

Identification

  • Product Name:Benzenesulfonamide,3-nitro-

  • CAS Number: 121-52-8

  • EINECS:204-477-8

  • Molecular Weight:202.191

  • Molecular Formula: C6H6N2O4S

  • HS Code:29350090

  • Mol File:121-52-8.mol

Synonyms:Benzenesulfonamide,m-nitro- (6CI,7CI,8CI);3-Nitrobenzolesulfamide;NSC407487;m-Nitrobenzenesulfonamide;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):IrritantXi

  • Hazard Codes:Xi

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Nitrobenzenesulfonamide >98.0%(HPLC)(N)
  • Packaging:25g
  • Price:$ 49
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TCI Chemical
  • Product Description:3-Nitrobenzenesulfonamide >98.0%(HPLC)(N)
  • Packaging:5g
  • Price:$ 17
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Nitrobenzenesulfonamide 99%
  • Packaging:25g
  • Price:$ 360
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:3-Nitrobenzenesulfonamide 99%
  • Packaging:5g
  • Price:$ 80.8
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:3-Nitrobenzenesulfonamide 95+%
  • Packaging:25 g
  • Price:$ 350
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Medical Isotopes, Inc.
  • Product Description:3-Nitrobenzenesulfonamide 95+%
  • Packaging:5 g
  • Price:$ 315
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Nitrobenzenesulfonamide 95+%
  • Packaging:5g
  • Price:$ 11
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Nitrobenzenesulfonamide 95+%
  • Packaging:25g
  • Price:$ 35
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Nitrobenzenesulfonamide 95+%
  • Packaging:100g
  • Price:$ 98
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:Labseeker
  • Product Description:3-NITROBENZENESULFONAMIDE 98
  • Packaging:250g
  • Price:$ 750
  • Delivery:In stock
  • Buy Now

Relevant articles and documentsAll total 18 Articles be found

Bone-seeking matrix metalloproteinase inhibitors for the treatment of skeletal malignancy

Laghezza, Antonio,Piemontese, Luca,Brunetti, Leonardo,Caradonna, Alessia,Agamennone, Mariangela,Di Pizio, Antonella,Pochetti, Giorgio,Montanari, Roberta,Capelli, Davide,Tauro, Marilena,Loiodice, Fulvio,Tortorella, Paolo

, (2020)

Matrix metalloproteinases (MMPs) are a family of enzymes involved at different stages of cancer progression and metastasis. We previously identified a novel class of bisphosphonic inhibitors, selective for MMPs crucial for bone remodeling, such as MMP-2. Due to the increasing relevance of specific MMPs at various stages of tumor malignancy, we focused on improving potency towards certain isoforms. Here, we tackled MMP-9 because of its confirmed role in tumor invasion, metastasis, angiogenesis, and immuno-response, making it an ideal target for cancer therapy. Using a computational analysis, we designed and characterized potent MMP-2/MMP-9 inhibitors. This is a promising approach to develop and clinically translate inhibitors that could be used in combination with standard care therapy for the treatment of skeletal malignancies.

Beech

, p. 515,516 (1970)

Synthesis, biological evaluation, and docking studies of novel pyrrolo[2,3-b]pyridine derivatives as both ectonucleotide pyrophosphatase/phosphodiesterase inhibitors and antiproliferative agents

Ullah, Saif,El-Gamal, Mohammed I.,El-Gamal, Randa,Pelletier, Julie,Sévigny, Jean,Shehata, Mahmoud K.,Anbar, Hanan S.,Iqbal, Jamshed

, (2021)

Ecto-nucleotide pyrophosphatases/phosphodiesterases (NPPs) together with nucleoside triphosphate diphosphohydrolases (NTPDases) and alkaline phosphatases (APs) are nucleotidases located at the surface of the cells. NPP1 and NPP3 are important members of NPP family that are known as druggable targets for a number of disorders such as impaired calcification, type 2 diabetes, and cancer. Sulfonylurea derivatives have been reported as antidiabetic and anticancer agents, therefore, we synthesized and investigated series of sulfonylurea derivatives 1a-m possessing pyrrolo[2,3-b]pyridine core as inhibitors of NPP1 and NPP3 isozymes that are over-expressed in cancer and diabetes. The enzymatic evaluation highlighted compound 1a as selective NPP1 inhibitor, however, 1c was observed as the most potent inhibitor of NPP1 with an IC50 value of 0.80 ± 0.04 μM. Compound 1l was found to be the most potent and moderately selective inhibitor of NPP3 (IC50 = 0.55 ± 0.01 μM). Furthermore, in vitro cytotoxicity assays of compounds 1a-m against MCF-7 and HT-29 cancer cell lines exhibited compound 1c (IC50 = 4.70 ± 0.67 μM), and 1h (IC50 = 1.58 ± 0.20 μM) as the most cytotoxic compounds against MCF-7 and HT-29 cancer cell lines, respectively. Both of the investigated compounds showed high degree of selectivity towards cancer cells than normal cells (WI-38). Molecular docking studies of selective and potent enzyme inhibitors revealed promising mode of interactions with important binding sites residues of both isozymes i.e., Thr256, His380, Lys255, Asn277 residues of NPP1 and His329, Thr205, and Leu239 residues of NPP3. In addition, the most potent antiproliferative agent, compound 1h, doesn't produce hypoglycemia as a side effect when injected to mice. This is an additional merit of the promising compound 1h.

SELECTIVE NON-CYCLIC NUCLEOTIDE ACTIVATORS FOR THE CAMP SENSOR EPAC1

-

Paragraph 00174-00176; 00198; 00275, (2021/09/26)

The invention relates generally to novel EPAC1 activators, such as Formula (I) and (II) and the preparation thereof as well as the use of EPAC1 activators disclosed herein as to selectively activate EPAC1 in cells.

KIF18A INHIBITORS

-

Paragraph 0322-0323, (2021/02/12)

Amide compounds of formula (I): and compositions containing them, and processes for preparing such compounds. Provided herein also are methods of treating disorders or diseases treatable by inhibition of Kinesin Motor Protein KIF18A, such as cancer, psoriasis, atopic dermatitis, an autoimmune disorder, or inflammatory bowel disease, and the like.

Synthesis and Biochemical Evaluation of Noncyclic Nucleotide Exchange Proteins Directly Activated by cAMP 1 (EPAC1) Regulators

Wang, Pingyuan,Luchowska-Stańska, Urszula,Van Basten, Boy,Chen, Haiying,Liu, Zhiqing,Wiejak, Jolanta,Whelan, Padraic,Morgan, David,Lochhead, Emma,Barker, Graeme,Rehmann, Holger,Yarwood, Stephen J.,Zhou, Jia

, p. 5159 - 5184 (2020/06/03)

Exchange proteins directly activated by cAMP (EPAC) play a central role in various biological functions, and activation of the EPAC1 protein has shown potential benefits for the treatment of various human diseases. Herein, we report the synthesis and biochemical evaluation of a series of noncyclic nucleotide EPAC1 activators. Several potent EPAC1 binders were identified including 25g, 25q, 25n, 25u, 25e, and 25f, which promote EPAC1 guanine nucleotide exchange factor activity in vitro. These agonists can also activate EPAC1 protein in cells, where they exhibit excellent selectivity toward EPAC over protein kinase A and G protein-coupled receptors. Moreover, 25e, 25f, 25n, and 25u exhibited improved selectivity toward activation of EPAC1 over EPAC2 in cells. Of these, 25u was found to robustly inhibit IL-6-activated signal transducer and activator of transcription 3 (STAT3) and subsequent induction of the pro-inflammatory vascular cell adhesion molecule 1 (VCAM1) cell-adhesion protein. These novel EPAC1 activators may therefore act as useful pharmacological tools for elucidation of EPAC function and promising drug leads for the treatment of relevant human diseases.

Process route upstream and downstream products

Process route

3-nitro-benzenesulfonic acid-(methyl-nitro-amide)
59263-05-7

3-nitro-benzenesulfonic acid-(methyl-nitro-amide)

ammonia
7664-41-7

ammonia

methylnitroamine
598-57-2

methylnitroamine

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
at 120 ℃;
3-nitrobenzenesulfonyl azide
6647-85-4

3-nitrobenzenesulfonyl azide

3-nitro-N-phenylbenzenesulfonamide
28791-26-6

3-nitro-N-phenylbenzenesulfonamide

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

1-(3-Nitro-benzenesulfonyl)-1H-azepine
132994-76-4

1-(3-Nitro-benzenesulfonyl)-1H-azepine

Conditions
Conditions Yield
at 140 ℃; for 0.666667h; under 41371.8 - 63092.1 Torr; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
at 140 ℃; for 0.666667h; under 41371.8 - 63092.1 Torr; Rate constant;
2-methyl-2-(3-nitrobenzenesulfonylamino)propionic acid

2-methyl-2-(3-nitrobenzenesulfonylamino)propionic acid

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With oxygen; copper(II) oxide; In dimethyl sulfoxide; at 100 ℃; for 8h;
93%
methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

3-nitro-aniline
99-09-2

3-nitro-aniline

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With pyridine; In dichloromethane; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;
46.5%
N-methylethyl-3-nitrobenzenesulfonamide
28860-10-8

N-methylethyl-3-nitrobenzenesulfonamide

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With chromium(III) acetate hydroxide; periodic acid; In acetonitrile; at 20 ℃; for 20h;
92%
N-isopropylidene-3-nitrobenzenesulfenamide
38205-95-7

N-isopropylidene-3-nitrobenzenesulfenamide

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
3-Nitro-benzenesulfinic acid isopropylidene-amide

3-Nitro-benzenesulfinic acid isopropylidene-amide

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With water; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
sodium 3-nitrobenzenesulfonate
127-68-4

sodium 3-nitrobenzenesulfonate

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: 19 percent / SOCl2 / dimethylformamide / 3 h / 0 - 20 °C
2: 40 percent / NH3; TEA; DMAP / tetrahydrofuran / 20 °C
With dmap; thionyl chloride; TEA; ammonia; In tetrahydrofuran; N,N-dimethyl-formamide;
nitrobenzene
98-95-3,26969-40-4

nitrobenzene

3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: chlorosulphuric acid / Heating; 1) mixture slightly heated; 2) room temperature, 2 h
2: ammonia / acetone; H2O / Ambient temperature
With chlorosulphuric acid; ammonia; In water; acetone;
3-nitrophenylsulfonamide
121-52-8

3-nitrophenylsulfonamide

Conditions
Conditions Yield
With ammonia;

Global suppliers and manufacturers

Global( 63) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
  • Amadis Chemical Co., Ltd.
  • Business Type:Lab/Research institutions
  • Contact Tel:86-571-89925085
  • Emails:sales@amadischem.com
  • Main Products:29
  • Country:China (Mainland)
  • Chemwill Asia Co., Ltd.
  • Business Type:Manufacturers
  • Contact Tel:021-51086038
  • Emails:sales@chemwill.com
  • Main Products:30
  • Country:China (Mainland)
  • Win-Win chemical Co.Ltd
  • Business Type:Lab/Research institutions
  • Contact Tel:0086-577-64498589
  • Emails:sales@win-winchemical.com
  • Main Products:55
  • Country:China (Mainland)
  • Kono Chem Co.,Ltd
  • Business Type:Other
  • Contact Tel:86-29-86107037-8015
  • Emails:info@konochemical.com
  • Main Products:83
  • Country:China (Mainland)
  • Hangzhou Dingyan Chem Co., Ltd
  • Business Type:Manufacturers
  • Contact Tel:86-571-86465881,86-571-87157530,86-571-88025800
  • Emails:sales@dingyanchem.com
  • Main Products:95
  • Country:China (Mainland)
  • GIHI CHEMICALS CO.,LIMITED
  • Business Type:Lab/Research institutions
  • Contact Tel:571-86217390
  • Emails:info@gihichem.com
  • Main Products:66
  • Country:China (Mainland)
  • Finetech Industry Limited
  • Business Type:Trading Company
  • Contact Tel:86-27-87465837
  • Emails:sales@finetechnology-ind.com
  • Main Products:29
  • Country:China (Mainland)
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 121-52-8
Post Buying Request Now
close
Remarks: The blank with*must be completed