1214940-01-8

Basic information

• Product Name: 2-(N-pyrrolidinyl)-3'-methylpropiophenone
• CAS NO: 1214940-01-8
• Molecular Weight: 217.311
• Mol File: 1214940-01-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-pyrrolidinyl)-3'-methylpropiophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-pyrrolidinyl)-3'-methylpropiophenone(1214940-01-8)
• EPA Substance Registry System: 2-(N-pyrrolidinyl)-3'-methylpropiophenone(1214940-01-8)

Safety Data

• Hazardous Substances Data: 1214940-01-8(Hazardous Substances Data)

Upstream product

• 123-75-1 pyrrolidine 
• 1451-83-8 2-bromo-1-(3-methylphenyl)propan-1-one 

Downstream Products

• 1214940-17-6 2-(N-pyrrolidinyl)-3'-methylpropiophenone fumarate 

Relevant articles and documents

Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation

Bupropion (2a) analogues were synthesized and tested for their ability to inhibit monoamine uptake and to antagonize the effects of human α3β4*, α4β2, α4β4, and α1 * nAChRs. The analogues were evaluated for their ability to block nicotine-induced effects in four tests in mice. Nine analogues showed increased monoamine uptake inhibition. Similar to 2a, all but one analogue show inhibition of nAChR function selective for human α3β4*-nAChR. Nine analogues have higher affinity at α3β4*-nAChRs than 2a. Four analogues also had higher affinity for α4β2 nAChR. Analogues 2r, 2m, and 2n with AD50 values of 0.014,0.015, and 0.028 mg/kg were 87,81, and 43 times more potent than 2a in blocking nicotine-induced antinociception in the tail-flick test. Analogue 2x with IC50 values of 31 and 180 nM for DA and NE, respectively, and with IC50 of 0.62 and 9.8 μm for antagonism of α3β4 and α4β2 nAChRs had the best overall in vitro profile relative to 2a.