121666-37-3

Basic information

• Product Name: Phosphonium, [(2E)-4-methoxy-3-methyl-4-oxo-2-butenyl]triphenyl-, bromide
• CAS NO: 121666-37-3
• Molecular Formula: C24H24O2P.Br
• Molecular Weight: 455.331
• Mol File: 121666-37-3.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Phosphonium, [(2E)-4-methoxy-3-methyl-4-oxo-2-butenyl]triphenyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, [(2E)-4-methoxy-3-methyl-4-oxo-2-butenyl]triphenyl-, bromide(121666-37-3)
• EPA Substance Registry System: Phosphonium, [(2E)-4-methoxy-3-methyl-4-oxo-2-butenyl]triphenyl-, bromide(121666-37-3)

Safety Data

• Hazardous Substances Data: 121666-37-3(Hazardous Substances Data)

Upstream product

• 6622-76-0 methyl (E)-2-methyl-2-butenoate 
• 80-59-1 Tiglic acid 
• 99968-60-2 methyl (E)-4-bromo-2-methylbut-2-enoate 
• 33935-64-7 methyl 2-(bromomethyl)-2-butenoate 
• 58588-88-8 Methyl-2(Z)-4-brom-2-brommethyl-2-butenoat 
• 603-35-0 triphenylphosphine 
• 5953-76-4 methyl angelate 

Downstream Products

• 345653-77-2 Methyl 15S-(tert-butyldiphenylsilyloxy)-7S-methoxy-2-methyl-2E,4E,10E-hexadecatrienoate 
• 345653-60-3 Methyl 15S-(tert-butyldiphenylsilyloxy)-7R-methoxy-2-methyl-2E,4E,10E-hexadecatrienoate 
• 5892-54-6 Crocetindimethylester 
• 64603-92-5 sodium (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate 
• 27876-94-4 crocetin 
• 129144-90-7 2-methyl-4-(triphenyl-λ⁵-phosphoranylidene)but-2-enoic acid methyl ester 
• 122647-35-2 (2R,5R)-8-hydroxy-2-trimethylsilyloxy-κ,χ-caroten-6-one 
• 65252-71-3 (3S,5R)-8-hydroxy-3-trimethylsilyloxy-κ,χ-caroten-6-one 
• 55906-76-8 trikentriorhodin 
• 122647-34-1 (2R,5R)-2,8-dihydroxy-κ,χ,caroten-6-one 
• 122673-54-5 (5R)-8-hydroxy-κ,χ-caroten-6-one 
• 65252-74-6 methyl 8'-apo-χ-carotenoate 
• 79750-66-6 3-(cis-2,3-Dihydro-2-phenyl-3-furyl)methacrylsaeure-methylester 
• 79750-66-6 3-(trans-2,3-Dihydro-2-phenyl-3-furyl)methacrylsaeure-methylester 

Relevant articles and documents

Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 μM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114.0 ± 8.0 and 113.0 ± 11.1 μM, respectively). The results described in this article suggest that saffron may be a helpful alimentary component in the prevention of cancer that potentially contributes to the efficacy of approved cancer therapies.

BIPOLAR TRANS CAROTENOID SALTS AND THEIR USE

PROBLEM TO BE SOLVED: To provide trans carotenoid salt compounds useful for improving the diffusibility of oxygen between red blood cells and a body tissue in mammalian including human being, a method for producing them, a method for solubilizing them, and a method for using them. SOLUTION: There are provided compounds represented by the following formula, and are compounds not being trans sodium crocetinate: YZ-TCRO-ZY[Y denotes a cation; Z denotes a polar group coupled to the cation; TCRO denotes a trans carotenoid skeleton; preferably, as follows; Y denotes the monovalent metal ion of Na+,K+ or Li+ or R4 N+ or R3S+;R denotes H or CnH2n+1;n denotes the integer of 1 to 10;Z denotes a carboxyl group, a sulfuric acid group, a mono-phosphoric acid group, a di-phosphoric acid group, or a tri-phosphoric acid group; and TCRO denotes a group using isopronoid in which the single bond and double bond of straight chain carbon and carbon as exemplified by the following formula is repeated (X respectively independently denotes H, a straight chain/branched carbon chain substituted/non-substituted with 1 to 10C halogen or a halogen)]. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPO&INPIT

Bipolar trans carotenoid salts and their uses

The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.