122151-32-0

Basic information

• Product Name: 1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine
• Synonyms: 1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine;(S)-2-(Benzyloxy)-1-(pyrrolidin-1-yl)propan-1-one;1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine（WS202926）
• CAS NO: 122151-32-0
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.30616
• EINECS: -0
• Mol File: 122151-32-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 369.2°C at 760 mmHg
• Flash Point: 177.1°C
• Appearance: /
• Density: 1.103g/cm3
• Vapor Pressure: 1.21E-05mmHg at 25°C
• Refractive Index: 1.543
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine(122151-32-0)
• EPA Substance Registry System: 1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine(122151-32-0)

Safety Data

• Hazardous Substances Data: 122151-32-0(Hazardous Substances Data)

Usage

General Description

1-[(2S)-2-(benzyloxy)propanoyl]pyrrolidine is a complex organic chemical compound that belongs to the class of organic compounds known as polypyrrolidones. Its systematic IUPAC name indicates it contains a pyrrolidine core structure, which is a saturated five-membered nitrogen-containing ring, and a benzyl group. The compound also features an acyl group attached to the pyrrolidine part, indicating its carboxylic acid derivative characteristic. The stereochemistry of the molecule is denoted by the (2S) prefix, which signifies that the compound contains a chiral center and its stereo-configuration is 'S'. Details concerning its physical properties, bioactivity, safety, or potential applications are typically specific to the context of its use or study.

InChI:InChI=1/C14H19NO2/c1-12(14(16)15-9-5-6-10-15)17-11-13-7-3-2-4-8-13/h2-4,7-8,12H,5-6,9-11H2,1H3/t12-/m0/s1

Upstream product

• 98-88-4 benzoyl chloride 
• 122151-38-6 (S)-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one 
• 100-44-7 benzyl chloride 

Downstream Products

• 81445-44-5 (S)-2-(benzyloxy)propanal 
• 184177-83-1 2-[(1S,2S)-1-ethyl-2-benzyloxypropyl]-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)piperazin-1-yl]phenyl]-3H-1,2,4-triazol-3-one 
• 183871-36-5 C₁₂H₂₀N₂O*C₁₈H₁₄O₈ 
• 184177-88-6 C₁₇H₂₈N₂O₃ 
• 183871-36-5 C₁₂H₂₀N₂O*C₁₈H₁₄O₈ 
• 170985-86-1 4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)methyl)-5-(2,4-difluorophenyl)tetrahydrofuran-3-yl)methoxy)phenyl)piperazin-1-yl)phenyl)-1-((2S,3S)-2-(benzyloxy)pentan-3-yl)-1H-1,2,4-triazol-5(4H)-one 

Relevant articles and documents

Efficient Stereoselective Synthesis of a Key Chiral Aldehyde Intermediate in the Synthesis of Picolinamide Fungicides

A highly stereoselective and efficient synthesis of (4S,5S,6S)-6-(benzyloxy)-5-phenoxy-4-propoxyheptanal, a key intermediate for syntheses of picolinamide fungicides, is described in this report. The synthesis features a scalable allylpropyl ether preparation, an efficient synthesis of the C1-C3 anti,syn-(S,S,S) stereotriad via a highly diastereoselective allylboration, and Cu-catalyzed phenylation of a sterically hindered secondary alcohol with BiPh3(OAc)2 followed by highly regioselective hydroformylation with the formation of a linear aldehyde. Excellent overall route efficiency was achieved (six steps and 39% yield) starting from readily available and inexpensive (S)-ethyl lactate.

A PROCESS FOR THE MANUFACTURE OF POSACONAZOLE

The present invention discloses an improved process for the manufacture of Posaconazole, an anti-fungal agent belonging to the category of substituted Tetrahydrofuran Triazole compound. The present invention further describes preparation of formula A and formula B, the key intermediates in the preparation of Posaconazole. The invention also discloses novel intermediates that are useful in the synthesis of Posaconazole.

Stereoselective titanium-mediated aldol reactions of α-benzyloxy methyl ketones

Good levels of 1,4-anti asymmetric induction are obtained in the TiCl 3(i-PrO)-mediated aldol reaction of chiral α-benzyloxy methyl ketones with a wide array of aldehydes. This methodology represents a new approach to substrate-controlled acetate aldol reactions capable of providing highly functionalized fragments in a straightforward manner, which may be useful in the design of more efficient syntheses.