1221746-53-7

Basic information

• Product Name: 5-methoxy-N-(3,4,5-trimethoxyphenyl)-acridone-4-carboxamide
• CAS NO: 1221746-53-7
• Molecular Weight: 434.448
• Mol File: 1221746-53-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-methoxy-N-(3,4,5-trimethoxyphenyl)-acridone-4-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methoxy-N-(3,4,5-trimethoxyphenyl)-acridone-4-carboxamide(1221746-53-7)
• EPA Substance Registry System: 5-methoxy-N-(3,4,5-trimethoxyphenyl)-acridone-4-carboxamide(1221746-53-7)

Safety Data

• Hazardous Substances Data: 1221746-53-7(Hazardous Substances Data)

Upstream product

• 88377-31-5 4-methoxy-9-oxoacridan-5-carboxylic acid 
• 24313-88-0 3,4,5-Trimethoxyaniline 

Relevant articles and documents

Synthesis of new acridone derivatives, inhibitors of NS3 helicase, which efficiently and specifically inhibit subgenomic HCV replication

A new goup of acridone derivatives, obtained by reaction of acridone-4-carboxylic acid derivatives with aromatic amines, was tested to determine the inhibitory properties toward the NS3 helicase of hepatitis C virus (HCV). Six compounds inhibited the NS3 helicase at low concentrations (IC 50 from 1.5 to 20 μM). The acridone derivatives probably act via intercalation into double-stranded nucleic acids with a strong specificity for double-stranded RNA, although an interaction with the enzyme cannot be excluded. Testing in the subgenomic HCV replicon system revealed that compounds 10 and 13 are efficient RNA replication inhibitors, with EC50 of 3.5 and 1 μM and therapeutic indexes of >28 and 20, respectively. Compound 16, with EC50 1000, is extremely specific and practically noncytotoxic at the concentrations tested, proving that the acridone derivatives may be regarded as potential antiviral agents. Although the mechanism of action of 16 in the replicon system remains unclear, it is the key lead compound for further development of anti-HCV drugs.