122203-21-8

Basic information

• Product Name: {[(E)-Hydroxyimino]-phenyl-methyl}-phosphonic acid dibutyl ester
• CAS NO: 122203-21-8
• Molecular Weight: 313.334
• Mol File: 122203-21-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {[(E)-Hydroxyimino]-phenyl-methyl}-phosphonic acid dibutyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: {[(E)-Hydroxyimino]-phenyl-methyl}-phosphonic acid dibutyl ester(122203-21-8)
• EPA Substance Registry System: {[(E)-Hydroxyimino]-phenyl-methyl}-phosphonic acid dibutyl ester(122203-21-8)

Safety Data

• Hazardous Substances Data: 122203-21-8(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 126-73-8 phosphoric acid tributyl ester 
• 18106-74-6 benzoyl-phosphonic acid dibutyl ester 

Relevant articles and documents

α-OXYIMINOPHOSPHONATES: CHEMICAL AND PHYSICAL PROPERTIES. REACTIONS, THEORETICAL CALCULATIONS, AND X-RAY CRYSTAL STRUCTURES OF (E) AND (Z)-DIMETHYL α-HYDROXYIMINOBENZYLPHOSPHONATES

Dialkyl α-oxyiminoalkylphosphonates, obtained by treatment of dialkyl acylphosphonates with hydroxylamine or methoxylamine, are mostly mixtures of E and Z isomers.Structural assignments of the oximes were based on X-ray crystallographic analysis of representative compounds: (E)- and (Z)-dimethyl α-hydroxyiminobenzylphosphonates .The (31)P n.m.r. chemical shifts of the E isomers always appear at lower field than those of the corresponding Z isomers.Thermal fragmentation of (1a) affords benzonitrile and dimethyl hydrogen phosphate, with (Z)-(1a) reacting faster than the E isomer. α-Oxyiminophosphonates undergo EZ isomerisation catalysed either by acid or by base under certain conditions, the E isomer being the thermodinamically more stable one.An E + Z mixture of dialkyl α-oxyiminophosphonates can be mono-de-alkylated by non-basic nucleophiles (e.g.NaI) to afford monoalkyl oxyiminophosphonates of unchanged isomeric composition.The geometrical isomers of α-hydroxyiminophosphonates differ in their behaviour under basic conditions.While treatment of (E)-(1a) with NaOH in boiling methanol leads, by mono-de-alkylation, to sodium methyl α-hydroxyiminobenzylphosphonate , under the same conditions (Z)-(1a) undergoes fragmentation, by C-P bond cleavage, to benzonitrile and dimethyl hydrogen phosphate.Control experiments established that the fragmentation of (Z)-α-hydroxyiminophosphonates involves an intramolecular attack on the phosphorous atom by the ionized Z oriented oxime oxygen.Similar differences in behaviour are noted between the isomers of the monoanions of α-hydroxyiminophosphonates.MNDO/H Calculations demonstrate the feasibility of forming internal hydrogen bonds in Z isomers, and their possible contribution to conformational preferences.Single-crystal X-ray diffraction studies of (E)- and (Z)-(1a), and (E)-(2b), clearly identified the geometric isomers and correlated them with (1H) and (31)P n.m.r. resonances.