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122299-11-0

EGLIN C (41-49) is a peptide chemical compound that functions as a potent and specific inhibitor of human neutrophil elastase (HNE), an enzyme implicated in inflammatory processes and tissue damage. As a synthetic analog of the natural elastase inhibitor elafin, EGLIN C (41-49) features a modified cysteine residue, which enhances its stability and efficacy. Its capacity to effectively inhibit HNE activity both in vitro and in vivo positions it as a potential candidate for the development of anti-inflammatory drugs and treatments.

122299-11-0

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122299-11-0 Usage

Uses

Used in Pharmaceutical Industry:
EGLIN C (41-49) is used as an anti-inflammatory agent for its ability to specifically inhibit the activity of human neutrophil elastase, a key enzyme in inflammatory processes. This targeted inhibition makes it a promising compound for the treatment of conditions such as chronic obstructive pulmonary disease (COPD), cystic fibrosis, and other inflammatory disorders.
Used in Research and Development:
In the field of anti-inflammatory therapeutics, EGLIN C (41-49) is utilized as a research compound to further understand the role of HNE in inflammation and to develop new treatments that can effectively manage inflammatory conditions without affecting other related enzymes, thereby increasing the safety and specificity of potential drugs.

Check Digit Verification of cas no

The CAS Registry Mumber 122299-11-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,2,9 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 122299-11:
(8*1)+(7*2)+(6*2)+(5*2)+(4*9)+(3*9)+(2*1)+(1*1)=110
110 % 10 = 0
So 122299-11-0 is a valid CAS Registry Number.
InChI:InChI=1/C48H78N12O15/c1-23(2)18-31(41(68)53-30(11-9-17-52-48(49)50)40(67)55-33(20-27-12-14-28(63)15-13-27)43(70)58-35(22-61)47(74)75)54-44(71)34(21-36(64)65)56-42(69)32(19-24(3)4)57-46(73)38(26(7)62)60-45(72)37(25(5)6)59-39(66)29-10-8-16-51-29/h12-15,23-26,29-35,37-38,51,61-63H,8-11,16-22H2,1-7H3,(H,53,68)(H,54,71)(H,55,67)(H,56,69)(H,57,73)(H,58,70)(H,59,66)(H,60,72)(H,64,65)(H,74,75)(H4,49,50,52)/t26-,29+,30+,31+,32+,33+,34+,35+,37+,38+/m1/s1

122299-11-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name (3S)-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-3-methyl-2-[[

1.2 Other means of identification

Product number -
Other names (3S)-4-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[[(2S)-1-[[(2S)-1,3-dihydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[[(2S)-2-[[(2S,3R)-3-hydroxy-2-[[(2S)-3-methyl-2-[[(2S)-pyrrolidine-2-carbonyl]amino]butanoyl]amino]butanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:122299-11-0 SDS

122299-11-0Downstream Products

122299-11-0Relevant articles and documents

Amino acids and peptides. XXXVII. Synthesis of stereoisomeric nonapeptides corresponding to sequence 41-49 of eglin c and examination of their inhibitory activity against human leukocyte cathepsin G and α-chymotrypsin

Fujii,Tsuboi,Asada,Nagamatsu,Yamamoto,Okada

, p. 1518 - 1521 (2007/10/02)

A nonapeptide, H-Ser-Pro-Val-Thr-Leu-Asp-Leu-Arg-Tyr-OH, corresponding to sequence 41-49 of eglin c inhibited leukocyte cathepsin G and α-chymotrypsin with K(i) values of 2.2 x 10-5 and 7.2 x 10-6 M, respectively, although eglin c it

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