122372-11-6

Basic information

• Product Name: 5-bromo-2-chloro-4-(β-styryl)pyrimidine
• Synonyms: 5-bromo-2-chloro-4-(β-styryl)pyrimidine
• CAS NO: 122372-11-6
• Molecular Weight: 295.566
• Mol File: 122372-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-chloro-4-(β-styryl)pyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-chloro-4-(β-styryl)pyrimidine(122372-11-6)
• EPA Substance Registry System: 5-bromo-2-chloro-4-(β-styryl)pyrimidine(122372-11-6)

Safety Data

• Hazardous Substances Data: 122372-11-6(Hazardous Substances Data)

Upstream product

• 36082-50-5 2,4-dichloro-5-bromopyrimidine 
• 66680-87-3 (2-phenylvinyl)tributylstannane 

Relevant articles and documents

Regiochemistry in Pd-Catalysed Organotin Reactions with Halopyrimidines

Chlorines in activated pyrimidine position is replaced by carbon substituents in Pd-catalysed reactions with organotin compounds.The 4(6)-position is more reactive than the 2-position allowing for regioselective coupling in 2,4(6)-dihalopyrimidines.A bromine substituent is required for coupling in the benzenoid 5-position.In 5-bromo-2,4-dichloropyrimidine the 4-chlorine is replaced before the 5-bromine and the latter before the 2-chloro substituent, all in a regioselective manner.The methodology can be used to introduce functionalized carbon substituents into any pyrimidine position.