1224288-92-9

Basic information

• Product Name: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
• Synonyms: 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile;5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile
• CAS NO: 1224288-92-9
• Molecular Formula: C₇H₃ClN₄
• Molecular Weight: 178.57852
• EINECS: -0
• Mol File: 1224288-92-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 138-142℃ (isopropanol )
• Appearance: /
• Density: 1.56±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -3.08±0.40(Predicted)
• CAS DataBase Reference: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile(1224288-92-9)
• EPA Substance Registry System: 5-Chloropyrazolo[1,5-a]pyriMidine-3-carbonitrile(1224288-92-9)

Safety Data

• Hazardous Substances Data: 1224288-92-9(Hazardous Substances Data)

Usage

General Description

5-Chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile is an organic compound with the chemical formula C7H3ClN4. It is a heterocyclic compound that contains a pyrazole ring and a pyrimidine ring. This chemical is commonly used in the pharmaceutical industry as a building block for the synthesis of various other organic compounds. It is also known for its potential biological activities, such as antitumor and antimicrobial properties. The compound is typically used as a reagent in organic synthesis and is an important intermediate in the production of pharmaceuticals and agrochemicals. Additionally, it may also have potential applications in the field of medicinal chemistry for the development of new drugs.

Upstream product

• 1224288-95-2 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1224288-95-2 5-hydroxypyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1621718-74-8 (E)-5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde oxime 
• 1256162-94-3 5-chloropyrazolo[1,5-a]pyrimidine-3-carbaldehyde 
• 29274-24-6 5-chloropyrazolo[1,5-a]pyrimidine 

Downstream Products

• 478081-98-0 N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide 
• 1224289-06-8 5-(3-aminophenyl)pyrazolo[1,5-a]pyrimidin-3-carbonitrile 
• 1224289-04-6 5-(3-nitrophenyl)pyrazolo[1,5-a]pyrimidin-3-carbonitrile 
• 1224289-08-0 N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide 
• 1260846-28-3 (R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 1621718-29-3 N-(5-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)-2-methoxypyridin-3-yl)-2,4-difluorobenzenesulfonamide 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO NTRK

This invention relates to inhibitors of NTRK comprising a pyrazolo[1,5-4]pyrimidine-3-carbonitrile structure. They are active against wild-type NTRK and its resistant mutants.

HETEROAROMATIC COMPOUNDS AS PI3 KINASE MODULATORS AND METHODS OF USE

The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (PI3 kinases) and mTOR, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.