1224289-08-0

Basic information

• Product Name: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide
• Synonyms: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide
• CAS NO: 1224289-08-0
• Molecular Weight: 277.285
• Mol File: 1224289-08-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide(1224289-08-0)
• EPA Substance Registry System: N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)acetamide(1224289-08-0)

Safety Data

• Hazardous Substances Data: 1224289-08-0(Hazardous Substances Data)

Upstream product

• 1224288-92-9 5-chloropyrazolo[1,5-a]pyrimidine-3-carbonitrile 
• 78887-39-5 3-Acetamidophenylboronic acid 

Downstream Products

• 478081-98-0 N-(3-(3-cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl)-N-ethylacetamide 

Relevant articles and documents

Synthetic studies connected with the preparation of N-[3-(3- cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethylacetamide, a zaleplon regioisomer

N-[3-(3-Cyanopyrazolo[1,5-a]pyrimidin-5-yl)phenyl]-N-ethyl-acetamide, a principal impurity of zaleplon, is prepared by Suzuki-Miyaura cross coupling reaction of the corresponding boronic acid and/or boronates with 5-chloropyrazolo[1,5-a]pyrimidin-3-carbonitrile (7). Various methods of preparation of both components are described, as well as approaches based on the final modification of the 5-(3-aminophenyl)-pyrazolo[1,5-a]pyrimidine-3- carbonitrile moiety prepared by Suzuki-Miyaura cross coupling. All the prepared compounds were unambiguouesly identified by NMR techniques. Spectral characteristics (IR, UV, MS) of these compounds are also given.