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122441-64-9

122441-64-9

Identification

Synonyms:methyl 3β-hydroxy-5β-cholane-12-one-24-oate acetate

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Relevant articles and documentsAll total 2 Articles be found

Synthesis of deuterium-labelled lithocholic acid

Baillie,Karls,Sjovall

, p. 849 - 859,852,854,855 (2007/10/16)

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An improved preparation of 3-alpha-acetoxy-11,20-diketo-(5-beta)-pregnane, the key intermediate in the synthesis of 11-oxygenated corticosteroids.

Stefanovic,Gasic,Hranisavljevic,Dermanovic

, p. 4799 - 4803 (2007/10/17)

-

Process route upstream and downstream products

Process route

3α-Acetoxy-12-oxo-cholansaeure-methylester
5143-55-5,99598-26-2,107436-96-4,107436-98-6,122441-64-9

3α-Acetoxy-12-oxo-cholansaeure-methylester

Conditions
Conditions Yield
3α-Acetoxy-11α-brom-12-oxo-cholansaeure-methylester (22), Propylmercaptan, CHCl3, Sieden, neben anderen nicht isolierten Verbb.;
3α-Acetoxy-12-oxo-cholansaeuremethylester
5143-55-5,99598-26-2,107436-96-4,107436-98-6,122441-64-9

3α-Acetoxy-12-oxo-cholansaeuremethylester

Conditions
Conditions Yield
3-O-Acetyl-desoxycholsaeuremethylester, CrO3;
(yield)81percent;
Methyl-3α-acetoxy-12-oxo-5β-cholanat
5143-55-5,99598-26-2,107436-96-4,107436-98-6,122441-64-9

Methyl-3α-acetoxy-12-oxo-5β-cholanat

Conditions
Conditions Yield
Deoxycholsaeure (I), 1) CH3OH, HCl, 2) Acetanhydrid, Py., 3) CrO3;
3α-Acetoxy-12-keto-cholansaeure-methylester
5143-55-5,99598-26-2,107436-96-4,107436-98-6,122441-64-9

3α-Acetoxy-12-keto-cholansaeure-methylester

Conditions
Conditions Yield
Alkohol III, CrO3;
methyl 3β-hydroxy-5β-cholane-12-one-24-oate acetate
122441-64-9

methyl 3β-hydroxy-5β-cholane-12-one-24-oate acetate

Deoxycholic acid
83-44-3

Deoxycholic acid

Conditions
Conditions Yield
Multi-step reaction with 5 steps
1: sodium hydroxide; methanol / 2 h / 20 °C
2: thionyl chloride / 1 h / 0 - 20 °C
3: pyridinium chlorochromate / dichloromethane / 20 °C
4: lithium tri-t-butoxyaluminum hydride / tetrahydrofuran / 20 °C / Inert atmosphere
5: water; lithium hydroxide / tetrahydrofuran / 20 °C
With methanol; thionyl chloride; water; lithium tri-t-butoxyaluminum hydride; pyridinium chlorochromate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; dichloromethane;
Multi-step reaction with 3 steps
1.1: sodium hydroxide; methanol / 2 h / 20 °C
1.2: 1 h / 0 - 20 °C
1.3: 4 h / 20 °C
2.1: LiAlH(O-tBu) / tetrahydrofuran / 0.5 h / 20 °C / Inert atmosphere
3.1: water; lithium hydroxide / tetrahydrofuran / 3 h / 20 °C
With methanol; water; sodium hydroxide; lithium hydroxide; In tetrahydrofuran;
Multi-step reaction with 5 steps
1: sodium hydroxide / methanol / 2 h / 20 °C
2: thionyl chloride / 1 h / 0 - 20 °C
3: pyridinium chlorochromate / dichloromethane / 20 °C
4: lithium tri-tert-butoxy aluminium hydride / tetrahydrofuran / 20 °C / Inert atmosphere
5: lithium hydroxide / tetrahydrofuran; water / 20 °C
With thionyl chloride; lithium tri-tert-butoxy aluminium hydride; pyridinium chlorochromate; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water;
methyl 3β-hydroxy-5β-cholane-12-one-24-oate acetate
122441-64-9

methyl 3β-hydroxy-5β-cholane-12-one-24-oate acetate

3β-hydroxy-12-oxo-5β-cholanoic acid-(24)
4560-58-1,83830-81-3

3β-hydroxy-12-oxo-5β-cholanoic acid-(24)

Conditions
Conditions Yield
With methanol; sodium hydroxide; at 20 ℃; for 2h;
With sodium hydroxide; In methanol; at 20 ℃; for 2h;

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