1224428-86-7Relevant articles and documents
Synthesis and biological evaluation of capsaicin derivatives as analgesia drugs
Qian, Hai,Fu, Zhixian,Zhang, Huibin,Zhou, Jinpei,Huang, Wenlong,Jin, Jing,Chen, Wei,Dai, Dongyan
experimental part, p. 122 - 127 (2011/02/22)
TRPV1 is an important analgesia target. Capsaicin, the prototypical TRPV1 agonist, has a clear therapeutic potential. But the highly pungency limited its use. In this letter, for lowering its pungency, a series of capsaicin derivatives were designed and s