122620-02-4

Basic information

• Product Name: 3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride
• Synonyms: 3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride
• CAS NO: 122620-02-4
• Molecular Weight: 603.028
• Mol File: 122620-02-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride(122620-02-4)
• EPA Substance Registry System: 3-carbamoyl-1-(tri-O-benzoyl-β-D-ribofuranosyl)-pyridinium; chloride(122620-02-4)

Safety Data

• Hazardous Substances Data: 122620-02-4(Hazardous Substances Data)

Upstream product

• 1824-96-0 methyl ribofuranoside 
• 50-69-1 D-ribose 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 98-92-0 nicotinamide 
• 5991-01-5 2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride 

Downstream Products

• 23111-00-4 3-carbamoyl-1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyridin-1-ium (β-D-nicotinamide riboside) 
• 1094-61-7 nicotinamide mononucleotide 

Relevant articles and documents

Application of nicotinamide riboside aromatic formate compound and composition thereof and compound crystal form

The invention provides application of a nicotinamide riboside triaryl formate compound and a composition thereof in improving the level of coenzyme I (NAD) in the human body, improving health conditions or treating related diseases, and a compound in a crystal form shown in the formula (II-1). The structure of the nicotinamide riboside triaryl formate compound is as shown in a formula (I). As a synthesis precursor of NAD, compared with nicotinamide nucleoside, the nicotinamide nucleoside triaryl formate compound not only can effectively improve the level of NAD in the human body, but also is easier to prepare, the cost is remarkably reduced, and the nicotinamide nucleoside triaryl formate compound has remarkable industrial application advantages.

PROCESS FOR THE PREPARATION OF NICOTINAMIDE RIBOSIDE CHLORIDE DERIVATIVES

It relates to a process for the preparation of nicotinamide riboside chloride of formula (I) wherein R1-R4 are as defined herein, comprising the following steps: a) reacting a riboside precursor wherein the hydroxyl groups at positions 1, 2, 3 and 5 of the ribose are protected with hydroxyl protective groups; with nicotinamide in the presence of a Lewis acid selected from SnCI4 and TiCI4 in an appropriate solvent, to give the corresponding protected nicotinamide riboside chloride compound, wherein the hydroxyl groups at positions 2, 3 and 5 are protected with hydroxyl protective groups; and b) removing the protective groups of the compound obtained in step a) to give a compound of formula (I). It also relates to a process for the preparation of the protected nicotinamide riboside chloride compound.