122731-58-2

Basic information

• Product Name: 3-(2,3-dihydroxypropylcarbamoyl)-5-nitro-benzoic acid
• Synonyms: 3-[(2,3-Dihydroxypropyl)carbamoyl]-5-nitrobenzoic acid
• CAS NO: 122731-58-2
• Molecular Formula: C₁₁H₁₂N₂O₇
• Molecular Weight: 284.22
• Mol File: 122731-58-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 611.3°C at 760 mmHg
• Flash Point: 323.5°C
• Density: 1.556g/cm³
• Vapor Pressure: 8.44E-16mmHg at 25°C
• Refractive Index: 1.638
• CAS DataBase Reference: 3-(2,3-dihydroxypropylcarbamoyl)-5-nitro-benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,3-dihydroxypropylcarbamoyl)-5-nitro-benzoic acid(122731-58-2)
• EPA Substance Registry System: 3-(2,3-dihydroxypropylcarbamoyl)-5-nitro-benzoic acid(122731-58-2)

Safety Data

• Hazardous Substances Data: 122731-58-2(Hazardous Substances Data)

Usage

General Description

3-(2,3-dihydroxypropylcarbamoyl)-5-nitro-benzoic acid is a chemical compound that consists of a benzoic acid ring with a nitro group and a carbamoyl group attached. It is also known as N-(2,3-dihydroxypropyl)-5-nitrosalicylamide and is used as an intermediate in the synthesis of pharmaceuticals and organic compounds. This chemical compound is not only used in pharmaceutical research and development, but it also has potential applications in the fields of agriculture and materials science. Its unique structure and properties make it a valuable building block for the synthesis of various compounds with diverse functionalities.

Upstream product

• 13290-96-5 dimethyl 5-nitroisophthalate 
• 618-88-2 5-nitrobenzene-1,3-dicarboxylic acid 
• 616-30-8 3-Amino-1,2-propanediol 
• 1955-46-0 5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester 
• 22871-55-2 5-nitroisophthalic acid monoethyl ester 

Downstream Products

• 73334-07-3 iopromide 
• 122731-74-2 5-amino-isophthalic acid mono-(2,3-dihydroxy-propyl) amide 

Relevant articles and documents

Preparation method and intermediates of iopromide

The present invention relates to a preparation method and intermediates of iopromide. The method specifically comprises: adopting a compound represented by a formula II as a starting raw material, and sequentially carrying out an acylation reaction, a lactonization reaction, a further acylation reaction, a reduction reaction, an iodination reaction, a re-acylation reaction and a final hydrolysis reaction to obtain the iopromide represented by a formula I, wherein a compound represented by a formula VII and a compound represented by a formula V are introduced as the intermediates so as to avoid the generation of the bismer by-product, the lactone ring is not easily subjected to ring opening removing during the iodination reaction process, and the introduced intermediates are easy to separate and purify, such that the high-purity iopromide can be prepared in the high-yield manner.

Synthesis of N1,N3-BIS(2,3-DIHYDROXYPROPYL)-5-NITROISOPHTHALAMIDE

The present disclosure generally relates to a new process for the preparation of high purity 5-nitro-isophthalamide compounds, which are useful as intermediates for the preparation of imaging agents, such as iodinated x-ray contrast imaging agents like ioversol, iohexyl and iopamidol.

Carboxamide non-ionic contrast media

Novel triiodo 5-aminoisophthaldiamides are provided, where the amino and one of the amide nitrogens are substituted. The compounds have at least two hydroxyl groups and are found to provide low viscosity and osmolality. Procedures for preparing the compounds are provided.