123040-94-8

Basic information

• Product Name: azasetron hydrochloride
• Synonyms: (+)-Azasetron hydrochloride
• CAS NO: 123040-94-8
• Molecular Formula: C17H20 Cl N3 O3 . Cl H
• Molecular Weight: 386.27
• Mol File: 123040-94-8.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: azasetron hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: azasetron hydrochloride(123040-94-8)
• EPA Substance Registry System: azasetron hydrochloride(123040-94-8)

Safety Data

• Hazardous Substances Data: 123040-94-8(Hazardous Substances Data)

Upstream product

• 76883-48-2 quinuclidin-3-amine 
• 123040-50-6 6-chloro-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzoxazine-8-carboxylic acid chloride 
• 120538-52-5 3-aminoquinuclidine monohydrochloride 
• 141761-83-3 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid methyl ester 
• 123040-69-7 azasetron 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 5043-79-8 5-chloro-2-hydroxy-3-nitrobenzoic acid methyl ester 
• 5043-81-2 3-amino-5-chloro-2-hydroxybenzoic acid methyl ester 

Relevant articles and documents

Novel preparation method of azasetron hydrochloride

The invention provides a novel preparation method of azasetron hydrochloride, belonging to the technical field of medicine synthesis. According to the method, methyl 5-chlorosalicylate is used as a raw material; after acetic anhydride nitrification and stannous chloride reduction at room temperature, dimethyl carbonate is used as a methylation reagent, and an intermediate V (6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-carboxylic acid methyl ester) is synthesized by adopting a one-pot method; the intermediate V is hydrolyzed to obtain 6-chloro-4-methyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazine-8-formic acid (VI); and the compound reacts with free 3-aminoquinuclidine dihydrochloride for 1 h under the catalysis of TBTU to form a salt so as to obtain I (azasetron hydrochloride). According to the method, the yield of each step is high; aftertreatment is simple; the reaction time of each step is short; conditions are mild; low-toxicity environment-friendly reagents are adopted; energy consumption is reduced; cost is saved; and industrial production is better facilitated.

A method for synthesizing arab League grips Si Qiong hydrochloric acid

The invention relates to new path azasetron hydrochloride, and belongs to the technical field of medicine. The method comprises the steps of taking 6-chlorine-4-methyl-3-keto-3,4-dihydro-2H-1,4-benzoxazine-8-methyl formate as a raw starting material, hydrolyzing into 6-chlorine-4-methyl-3-keto-3,4-dihydro-2H-1,4-benzoxazine-8-formic acid in an alcohol-alkali aqueous solution, activating carboxylic acid with TBTU (O-(Benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate), condensing with 3-aminoquinuclidine dihydrochloride directly, and finally salifying with concentrated hydrochloric acid to prepare azasetron hydrochloride. According to the method, TBTU serves as a condensing reagent, so that the reaction steps are simplified, pollution to an environment and equipment is reduced, aftertreatment is more convenient, later purification is easier, and industrial production of a product is facilitated further.

A hydrochloric acid arab League grips Si Qiong method for the preparation of

The invention discloses a method for preparing azasetron hydrochloride. The method comprises the following steps: hydrolyzing 6-chloro-4-methyl-3-oxo-3,4- dihydro-2H-1,4-benzoxazine-8-carboxylic acid methyl ester which serves as an initial material to prepare carboxylic acid; condensing with 2,2'-dibenzothiazyl disulfide under the action of triethylamine and triethyl phosphite to prepare active ester of carboxyl-2-benzothiazolyl thioester; directly condensing with a 3-aminoquinuclidine alkaline aqueous solution without separation, and salifying to prepare the azasetron hydrochloride. The method can be used for avoiding multiple steps of reaction and pollution to environment, has mild reaction condition and relatively high yield, and is suitable for industrialization.

Benzoxazine compounds and pharmaceutical use thereof

Benzoxazine compounds of the formula: STR1 wherein each symbol is as defined in the specification. The compounds exhibit 5-HT3 receptor antagonistic activity so that they are useful as antiemetics and so on.