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Cas Database

1233713-10-4

1233713-10-4

Identification

Synonyms:2,2,2-trifluoro-1-(4-isopropyl-3-nitrophenyl)ethanone

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Relevant articles and documentsAll total 1 Articles be found

M -Azipropofol (AziP m) a photoactive analogue of the intravenous general anesthetic propofol

Hall, Michael A.,Xi, Jin,Lor, Chong,Dai, Shuiping,Pearce, Robert,Dailey, William P.,Eckenhoff, Roderic G.

experimental part, p. 5667 - 5675 (2010/11/04)

Propofol is the most commonly used sedative-hypnotic drug for noxious procedures, yet the molecular targets underlying either its beneficial or toxic effects remain uncertain. In order to determine targets and thereby mechanisms of propofol, we have synthesized a photoactivateable analogue by substituting an alkyldiazirinyl moiety for one of the isopropyl arms but in the meta position. m-Azipropofol retains the physical, biochemical, GABAA receptor modulatory, and in vivo activity of propofol and photoadducts to amino acid residues in known propofol binding sites in natural proteins. Using either mass spectrometry or radiolabeling, this reagent may be used to reveal sites and targets that underlie the mechanism of both the desirable and undesirable actions of this important clinical compound.

Process route upstream and downstream products

Process route

2,2,2-trifluoro-1-(4-isopropylphenyl)ethan-1-one
124211-72-9

2,2,2-trifluoro-1-(4-isopropylphenyl)ethan-1-one

2,2,2-trifluoro-1-(4-isopropyl-3-nitrophenyl)ethanone
1233713-10-4

2,2,2-trifluoro-1-(4-isopropyl-3-nitrophenyl)ethanone

Conditions
Conditions Yield
2,2,2-trifluoro-1-(4-isopropylphenyl)ethan-1-one; With sulfuric acid; at -10 - -5 ℃;
With nitric acid; at -5 ℃; for 0.416667h;
88%
2,2,2-trifluoro-1-(4-isopropyl-3-nitrophenyl)ethanone
1233713-10-4

2,2,2-trifluoro-1-(4-isopropyl-3-nitrophenyl)ethanone

1-(3-amino-4-isopropylphenyl)-2,2,2-trifluoroethanone
1233713-11-5

1-(3-amino-4-isopropylphenyl)-2,2,2-trifluoroethanone

Conditions
Conditions Yield
With palladium 10% on activated carbon; hydrogen; In acetic acid; at 20 ℃; for 48h; under 760.051 Torr;
100%

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