1235990-53-0

Basic information

• Product Name: 6-amino-4-(4-chlorophenyl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile
• Synonyms: 6-amino-4-(4-chlorophenyl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile
• CAS NO: 1235990-53-0
• Molecular Weight: 300.747
• Mol File: 1235990-53-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 6-amino-4-(4-chlorophenyl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-4-(4-chlorophenyl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile(1235990-53-0)
• EPA Substance Registry System: 6-amino-4-(4-chlorophenyl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile(1235990-53-0)

Safety Data

• Hazardous Substances Data: 1235990-53-0(Hazardous Substances Data)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 99-91-2 para-chloroacetophenone 
• 109-77-3 malononitrile 

Relevant articles and documents

Multicomponent synthesis of dihydropyrano[2,3-c]pyrazoles catalyzed by lipase from Aspergillus niger

Lipase from Aspergillus niger (ANL) was found to be an extremely effective catalyst for four-component synthesis of dihydropyrano[2,3-c]pyrazoles from a stoichiometric mixture of ethyl acetoacetate, hydrazine hydrate, aldehyde/ketone, and malononitrile in

Solvent-free multicomponent synthesis of pyranopyrazoles: per-6-amino-β-cyclodextrin as a remarkable catalyst and host

A simple, green and efficient protocol is developed with per-6-amino-β-cyclodextrin (per-6-ABCD) which acts simultaneously as a supramolecular host and as an efficient solid base catalyst for the solvent-free syntheses of various dihydropyrano[2,3-c]pyrazole derivatives involving a four-component reaction. This atom-economical protocol, reported for the first time with ketones also, includes a much milder procedure, does not involve any tedious work-up or purification, avoids hazardous reagents/byproducts and results in near quantitative yields. The catalyst can be reused at least six times without any change in its catalytic activity.