123638-00-6

Basic information

• Product Name: 2-CHLORO-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID
• Synonyms: RARECHEM AL BE 0885;2-CHLORO-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID
• CAS NO: 123638-00-6
• Molecular Formula: C₁₁H₈ClNO₂
• Molecular Weight: 221.64
• Mol File: 123638-00-6.mol

Chemical Properties

• Boiling Point: 377.3±37.0 °C(Predicted)
• Appearance: /
• Density: 1.406±0.06 g/cm3(Predicted)
• PKA: 2.11±0.30(Predicted)
• CAS DataBase Reference: 2-CHLORO-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID(123638-00-6)
• EPA Substance Registry System: 2-CHLORO-6-METHYL-QUINOLINE-3-CARBOXYLIC ACID(123638-00-6)

Safety Data

• Hazardous Substances Data: 123638-00-6(Hazardous Substances Data)

Upstream product

• 73568-27-1 2-chloro-6-methylquinoline-3-carbaldehyde 
• 106-49-0 p-toluidine 
• 103-89-9 4-Methylacetanilide 

Downstream Products

• 1211543-08-6 C₁₉H₁₂N₄O₂S 
• 1211543-12-2 C₁₉H₁₁ClN₄OS 
• 1211543-04-2 C₁₉H₁₂N₄OS 

Relevant articles and documents

Synthesis and Bioactivity of Quinoline-3-carboxamide Derivatives

Twelve novel substituted 2-chloroquinoline-3-carboxamide derivatives were prepared from acetanilides using the Vilsmeier–Haack reaction, producing 2-chloro-3-carbaldehyde quinolines, followed by oxidation of the 3-carbaldehyde to the carboxylic acid and coupling this group with various anilines. The structures of the synthesized compounds were confirmed by NMR, mass spectrometry, and single crystal X-ray diffraction. The chemical shifts of H-5 and H-8 were shown to be influenced by the substituent at C-6. The substituent at C-6 was also seen to affect the chemical shift of C-5, C-7, and C-8, with C-5 and C-7 being more shielded in 5j (F substituted) in comparison with 5g (Cl substituted) and 5d (CH3 substituted). The compounds showed weak activity in the mM range against Gram-positive and Gram-negative bacteria of which 5b, 5d, and 5f showed the best activity with minimum bactericidal concentration values for 5b being 3.79?mM against methicillin-resistant Staphylococcus aureus and 5d and 5f having minimum bactericidal concentration values of 3.77 and 1.79?mM against S.?aureus ATCC 25923, respectively.

New 2-phenylquinoline derivatives: Synthesis and preliminary evaluation as antimicrobial agents

A number of new 2-phenylquinoline derivatives have been synthesized. All the synthesized compounds were evaluated for their antibacterial activity. Most of them showed a good activity against Escherichia coli and Staphylococcus aureus. The minimum inhibit

Synthesis of Novel Quinobenzodiazepin-12-ones

The synthesis of potentially biologically active quinobenzodiazepin-12-ones has been reported for the first time by the reaction of 2-chloroquinoline-3-carboxylic acids with o-phenylenediamine.