123701-04-2

Basic information

• Product Name: (8β)-N-<6-methyl-1-(1-methylethyl)ergolin-8-yl>-4-methoxycyclohexanecarboxamide
• CAS NO: 123701-04-2
• Molecular Weight: 423.599
• Mol File: 123701-04-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (8β)-N-<6-methyl-1-(1-methylethyl)ergolin-8-yl>-4-methoxycyclohexanecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: (8β)-N-<6-methyl-1-(1-methylethyl)ergolin-8-yl>-4-methoxycyclohexanecarboxamide(123701-04-2)
• EPA Substance Registry System: (8β)-N-<6-methyl-1-(1-methylethyl)ergolin-8-yl>-4-methoxycyclohexanecarboxamide(123701-04-2)

Safety Data

• Hazardous Substances Data: 123701-04-2(Hazardous Substances Data)

Upstream product

• 95233-12-8 4-methoxycyclohexylcarboxylic acid 
• 119154-51-7 (8β)-1-(methylethyl)-6-methylergoline-8-amine 

Relevant articles and documents

(8β)-6-Methylergoline amide derivatives as serotonin antagonists: N1-substituent effects on vascular 5HT2 receptor activity

A series of (8β)-6-methylergoline amide derivatives was synthesized with various alkyl substituents in the N1-position in order to evaluate their effectiveness in blocking vascular 5HT2 receptors. The influence of both the N1 substituent and amide derivative proved to be of great importance on binding affinities to vascular 5HT2 receptors. Within each series of amides, however, maximum affinity was achieved with an N1-isopropyl substituent (14, 18, 26, 38, and 41; all with 2.7-5.0 times greater affinity than their N1-H analogues), with the exception of two cases (22 and 37) in the cyclohexylamide derivatives wherein N1-methyl equalled the isopropyl in potency. Other than these exceptions, affinities followed the pattern of H Me Et iPr, with potencies falling off with larger alkyl substituents.