1237051-62-5

Basic information

• Product Name: 4-(2,5-dichlorothien-3-yl)-2-(2-methoxyphenyl)-1,3-thiazole
• CAS NO: 1237051-62-5
• Molecular Weight: 342.27
• Mol File: 1237051-62-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-(2,5-dichlorothien-3-yl)-2-(2-methoxyphenyl)-1,3-thiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2,5-dichlorothien-3-yl)-2-(2-methoxyphenyl)-1,3-thiazole(1237051-62-5)
• EPA Substance Registry System: 4-(2,5-dichlorothien-3-yl)-2-(2-methoxyphenyl)-1,3-thiazole(1237051-62-5)

Safety Data

• Hazardous Substances Data: 1237051-62-5(Hazardous Substances Data)

Upstream product

• 59160-46-2 2-bromo-1-(2,5-dichlorothien-3-yl)ethanone 
• 42590-97-6 2-methoxythiobenzamide 

Relevant articles and documents

Synthesis, characterization, in vitro and molecular docking studies of new 2,5-dichloro thienyl substituted thiazole derivatives for antimicrobial properties

A new series of 2-substituted 4-(2,5-dichloro thienyl)-1,3-thiazoles are synthesized by the reaction of 2-bromo-1-(2,5-dichlorothien-3-yl) ethanone with thiourea and substituted thioamides. The newly synthesized compounds 4aee are characterized by analytical 1H NMR,13C NMR and mass spectral data. The newly synthesized compounds are screened for antifungal and antibacterial activities. Among them 4a and 4d exhibited good antifungal and antibacterial activities. The newly synthesized compounds are subjected to molecular docking studies for the inhibition of the enzyme L-glutamine: D-fructose-6-phosphate amido-transferase [GlcN-6-P] (EC 2.6.1.16) which is a new target for antifungals. Among the five molecules taken for docking studies 2-(8-quinolinyl)-4-(2,5-dichloro thienyl)-1,3-thiazole 4d shows minimum binding and docking energy and may be considered as good inhibitor of GlcN-6-P synthase.