123715-02-6Relevant articles and documents
An Efficient and Highly Asymmetric Synthesis of (S)-2’,6’-Dimethyltyrosine
He, Kailun,Zhu, Fangmeng,Li, Hua,Tang, Jian,Zhang, Xingxian
, p. 510 - 516 (2020)
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Preparation method of 2,6-dimethyl-L-tyrosine
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Paragraph 0056-0066, (2019/01/05)
The invention discloses a preparation method of 2,6-dimethyl-L-tyrosine. The preparation method comprises the steps as follows: halide is added to an organic solvent and subjected to an SN2 nucleophilic addition reaction with L-camphor glycinate under the alkaline condition to produce a chiral compound (III); a compound (IV) is obtained after removal of a chiral auxiliary group from the compound (III); the target compound 2,6-dimethyl-L-tyrosine is obtained after removal of a protecting group from the compound (IV). The method has the characteristics that raw materials are cheap and easy to obtain, the reaction route is short, the operation is convenient, the yield and the stereoselectivity are high and the like, and the method has higher industrial application and economic value.
PROCESSES FOR PREPARING PHARMACEUTICALLY RELEVANT PEPTIDES
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Paragraph 0155, (2016/09/26)
The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some embodiments, the peptide is D-Arg-2′6′-Dmt-Lys-Phe-NH2.