123978-95-0Relevant articles and documents
Novel compound, adhesive composition, adhesive film and display device
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Paragraph 0098; 0105-0107, (2018/02/10)
The present invention relates to a novel compound, an adhesive composition comprising the same, an adhesive film made of the adhesive composition, and a display device comprising the adhesive film, wherein the novel compound according to the present invention is an acrylic compound which is a copolymer obtained by copolymerizing a diphenyl-oxadiazine main chain in a molecular structure with a monomer having an ester group and a terminal group capable of thermal polymerization with a linking ring, and has excellent thermal stability and optical characteristics, and the adhesive film comprising the same can realize excellent transparency, thermal stability and flexibility.COPYRIGHT KIPO 2017
Synthesis and anticancer properties of phenyl benzoate derivatives possessing a terminal hydroxyl group
Fukushi, Yukako,Yoshino, Hironori,Ishikawa, Junya,Sagisaka, Masanobu,Kashiwakura, Ikuo,Yoshizawa, Atsushi
, p. 1335 - 1343 (2014/03/21)
To assess the cytotoxic effects on A549 human lung cancer cells, we investigated a liquid-crystalline compound possessing a terminal hydroxyl group at concentrations of 0.1-20 μM. The compound, 4-butylphenyl 4-(6-hydroxyhexyloxy)benzoate (2), showed marked cell-growth inhibition at concentrations higher than 5 μM. Cell accumulation in the Sub-G1 phase indicating apoptosis was observed only at the highest concentration. Dynamic light scattering measurements show that the molecules form a spherical nanoparticle with a diameter of 130-170 nm at concentrations of 5-20 μM. We prepared the corresponding dimeric compounds and investigated their anticancer activity. The 1,2-benzene derivative, 1,2-bis[4-(6-hydroxyhexyloxy)benzoyloxy] benzene (4), exhibited cell-growth inhibition without affecting the cell cycle. However, the 1,3-benzene derivative, 1,3-bis[4-(6-hydroxyhexyloxy)benzoyloxy] benzene (5), was found to induce marked cell accumulation in the Sub-G1 phase. Furthermore, we assessed the cytotoxic effects of compounds 2, 4 and 5 on SW480 colon cancer cells and THP1 leukemic cells, as well as on WI-38 normal fibroblast cells. Both compounds 2 and 5 suppressed the growth of the solid cancer cells (A549 and SW480) more strongly compared with that of the hematological cancer cells (THP1). Unexpectedly, they also exhibited a strong cytotoxicity against the normal cells. We discuss the structure-property relationship in the anticancer activity of the mesogenic compounds.
Compounds and their application as well as a method of producing liquid crystalline polymers therefrom
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, (2008/06/13)
The invention relates to compounds with the general formula Y1 --A1 --M1 --A2 --Y2 wherein Y1 and Y2 are different from each other and Y1 is an acrylate or methacrylate residue and Y2 is a vinyl ether, epoxy, or azide residue, A1 and A2 are identical or different residues with the general formula Cn H2n in which n is a whole number from 0 to 20 and one or more methylene groups can be replaced by oxygen atoms, and M1 has the general formula --R1 --X1 --R2 --X2 --R3 --X3 --R4 -- wherein R1, R2, R3, and R4 are identical or different doubly bonded residues from the group --O--, --COO--, --CONH--, --CO--, --S--, --C C--, --CH=CH--, --CH=N--, --CH2 --, --N=N--, and --N=N(O)--, and R2 --X2 --R3 can also be a C--C bond, and X1, X2, and X3 are identical or different residues from the group 1,4-phenylene, 1,4-cyclohexylene; arylalkane or heteroarylalkane with 1 to 10 carbon atoms which contains one to three heteroatoms from the group O, N, and S, substituted with B1, B2, and/or B3 ; and cycloalkylene with 1 to 10 carbon atoms and substituted with B1, B2, and/or B3, wherein B1, B2, and B3 can be identical or different substituents from the group --H, C1 -C20 -alkyl, C1 -C20 -alkoxy, C1 -C20 -alkylthio, C1 -C20 -alkylcarbonyl, C1 -C20 -alkoxycarbonyl, C1 -C20 -alkylthiocarbonyl, --OH, halogen (fluorine, chlorine, bromine, iodine), --CN, --NO2, cycloalkyl, formyl, acetyl, and alkyl, alkoxy, or alkylthio residues with 1-20 carbon atoms interrupted by ether oxygen, thioether sulfur, or ester groups.