Welcome to LookChem.com Sign In|Join Free

Cas Database

124-63-0

124-63-0

Identification

  • Product Name:Methanesulfonyl chloride

  • CAS Number: 124-63-0

  • EINECS:204-706-1

  • Molecular Weight:114.553

  • Molecular Formula: CH3ClO2S

  • HS Code:HYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE Colourless To Pale Yellow Fuming Liquid

  • Mol File:124-63-0.mol

Synonyms:Methane Sulfonyl Chloride;Methyl sulfonyl chloride;Chloro methyl sulfone;Mesyl chloride;Methylsulfonyl chloride;Methanesulfonic acid chloride;Methyl sulfochloride;Chloromethyl sulfone;

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Pictogram(s):VeryT+,ToxicT,CorrosiveC

  • Hazard Codes:T+,T,C

  • Signal Word:Danger

  • Hazard Statement:H301 Toxic if swallowedH311 Toxic in contact with skin H314 Causes severe skin burns and eye damage H317 May cause an allergic skin reaction H330 Fatal if inhaled H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled Fresh air, rest. Refer for medical attention. In case of skin contact Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention . In case of eye contact First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention. If swallowed Rinse mouth. Do NOT induce vomiting. Refer for medical attention . Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. (ERG, 2016) Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Aggressive airway control may be needed. Watch for signs of respiratory insufficiency and assist ventilations if necessary. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... Monitor for shock and treat if necessary ... Anticipate seizures and treat if necessary ... For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool. Administer activated charcoal ... /Organophosphates and related compounds/

  • Fire-fighting measures: Suitable extinguishing media If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible Use "alcohol" foam, dry chemical or carbon dioxide. Excerpt from ERG Guide 156 [Substances - Toxic and/or Corrosive (Combustible / Water-Sensitive)]: Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. (ERG, 2016) Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Evacuate danger area! Consult an expert! Personal protection: complete protective clothing including self-contained breathing apparatus. Collect leaking and spilled liquid in sealable dry containers as far as possible. Absorb remaining liquid in sand or inert absorbent. Then store and dispose of according to local regulations. Do NOT wash away into sewer. Environmental considerations- land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Separated from food and feedstuffs. Dry. Well closed. Keep in a well-ventilated room.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Relevant articles and documentsAll total 54 Articles be found

-

Proell,Adams,Shoemaker

, p. 1129 (1948)

-

-

Field,Settlage

, p. 170 (1955)

-

-

Douglass,Norton

, p. 2104 (1968)

-

Synthesis of methanesulfonyl chloride (MSC) from methane and sulfuryl chloride

Mukhopadhyay, Sudip,Zerella, Mark,Bell, Alexis T.,Srinivas, R. Vijay,Smith, Gary S.

, p. 472 - 473 (2004)

Methane is transformed selectively to methanesulfonyl chloride at low temperature by liquid-phase reaction of methane with SO2Cl 2 in the presence of a free radical initiator and a promoter using 100% H2SO4 as the solvent.

Experimental study on deep desulfurization of MTBE by electrochemical oxidation and distillation

Li, Jing-Jing,Zhou, Fei,Tang, Xiao-Dong,Hu, Tao,Cheng, Jin

, p. 4803 - 4809 (2016)

With the increasing awareness of environmental protection, deep desulfurization of methyl tert-butyl ether (MTBE), which is the most important octane booster in gasoline, is extremely urgent. Herein, a new desulfurization method, involving the combination of electrochemical oxidation and distillation, is proposed to reduce the sulfur content in MTBE. Under optimum operating conditions, the sulfur content of real MTBE decreases from 132.5 μg g-1 to 2.3 μg g-1 and the desulfurization efficiency reaches 98.25%. The oxidation products with high boiling points can be separated by distillation. FTIR analyses prove that electrochemical oxidation has no influence on the main properties of MTBE. Moreover, GC/MS is used to study the conversion of model organic sulfides (dimethyl disulfide, diethyl sulfide and butyl mercaptan) in the electrochemical oxidative desulfurization process. Finally, the possible reaction mechanism of the electrochemical oxidative desulfurization of MTBE is proposed.

Novel One-Step Synthesis of Sulfonyl Chlorides from Sulfides with Iodosobenzene and Hydrogen Chloride-Treated Silica Gel

Sohmiya, Hajime,Kimura, Takahide,Fujita, Mitsue,Ando, Takashi

, p. 891 - 892 (1992)

Alkyl and aryl benzyl sulfides were conveniently converted into the corresponding alkyl and aryl sulfonyl chlorides in high yields with a few minutes' pulverization of solid mixtures with iodosobenzene and hydrogen chloride-treated silica gel.

-

Norton et al.

, p. 3645 (1967)

-

Preparation of methanesulfonyl chloride d3 from dimethyl sulfoxide d6

Hanai,Okuda

, p. 815 - 816 (1977)

-

A practical and efficient method for the preparation of sulfonamides utilizing Cl3CCN/PPh3

Chantarasriwong, Oraphin,Jang, Doo Ok,Chavasiri, Warinthorn

, p. 7489 - 7492 (2006)

Cl3CCN in combination with PPh3 proved to be a highly reactive reagent for the conversion of sulfonic acids to the corresponding sulfonyl chlorides in refluxing CH2Cl2. Upon reaction with amines, the corresponding sulfonamides were obtained in good to excellent yields.

-

Bennett et al.

, p. 2485 (1963)

-

-

Noller,Hearst

, p. 3955 (1948)

-

Novel anti-cancer agents based on germacrone: design, synthesis, biological activity, docking studies and MD simulations

Ye, Lianbao,Wu, Jie,Chen, Weiqiang,Feng, Yu,Shen, Zhibing

, p. 3760 - 3767 (2017)

Germacrone is a major activity component found in Curcuma zedoaria oil product, which is extracted from Curcuma zedoaria. In the present study, novel germacrone derivatives were first designed based on the theories of bioalkylating agents, synthesized, and then investigated for their inhibition effects on Bel-7402, HepG2, A549, and HeLa cells. Moreover, the study also evaluated the inhibition of these derivatives on c-Met kinase, which is expressed in a number of cancers. The results indicated that most of the compounds showed a stronger inhibitory effect on cancer cells and c-Met kinase than germacrone. Besides these findings, molecular docking studies were also carried out to analyze the results and explain the molecular mechanism of activities to c-Met kinase. Molecular dynamics simulations have been carried out for the further evaluation of binding stabilities between the compounds and their receptors.

FTIR Kinetic and Mechanistic Study of the Atmospheric Chemistry of Methyl Thiolformate

Patroescu, Iulia V.,Barnes, Ian,Becker, Karl H.

, p. 17207 - 17217 (1996)

Some aspects of the atmospheric chemistry of methyl thiolformate (CH3SCHO), a recently detected intermediate in the oxidation of dimethyl sulfide, have been investigated at 298 K and 1000 mbar total pressure in large reaction chambers using long path in situ FTIR absorption spectroscopy for the analysis.Rate coefficients of (1.11 +/- 0.22)E-11 and (5.80 +/- 0.80)E-11 cm3 molecule-1 s-1 have been determined for its reaction with OH radicals and Cl atoms, respectively.The UV spectrum of CH3SCHO has been measured in the range 220-355 nm and a lower limit of 5.4 days determined for its atmospheric photolytic lifetime.Detailed product analyses have made for the OH and Cl initiated photooxidation of CH3SCHO.Strong SO absorption bands observed in both systems are tentatively assigned to CH3SOCHO in the OH system and to CH3SOCl in the Cl system.The first gas-phase spectra of CH3SCl and CH3SOCl are also presented.The results are discussed with respect to the atmospheric chemistry of CH3SCHO and possible consequences for the photooxidation mechanism of dimethyl sulfide.

METHOD FOR PRODUCING TRIAZOLE COMPOUND

-

, (2020/02/05)

A compound represented by formula (5)can be produced by simultaneously and separately adding a compound represented by formula (4)and methanesulfonyl chloride to a compound represented by formula (3)and a compound represented by formula (6)having excellent control efficacies against pests can be produced by subjecting the compound represented by formula (5) to intramolecular condensation in the presence of an acid.

Selective Late-Stage Sulfonyl Chloride Formation from Sulfonamides Enabled by Pyry-BF4

Gómez-Palomino, Alejandro,Cornella, Josep

supporting information, p. 18235 - 18239 (2019/11/13)

Reported here is a simple and practical functionalization of primary sulfonamides, by means of a pyrylium salt (Pyry-BF4), with nucleophiles. This simple reagent activates the poorly nucleophilic NH2 group in a sulfonamide, enabling the formation of one of the best electrophiles in organic synthesis: a sulfonyl chloride. Because of the variety of primary sulfonamides in pharmaceutical contexts, special attention has been focused on the direct conversion of densely functionalized primary sulfonamides by a late-stage formation of the corresponding sulfonyl chloride. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides, sulfonates, sulfides, sulfonyl fluorides, and sulfonic acids. The mild reaction conditions and the high selectivity of Pyry-BF4 towards NH2 groups permit the formation of sulfonyl chlorides in a late-stage fashion, tolerating a preponderance of sensitive functionalities.

METHOD OF CONVERTING ALKANES TO ALCOHOLS, OLEFINS AND AROMATICS

-

Paragraph 0052-0053, (2019/08/08)

A cost-effective and energy-efficient process is disclosed for converting a methane-containing gas to a methane sulfonyl halide comprising reacting the methane-containing gas, under illumination by a light emitting diode (LED) source, with a sulfuryl halide or a halogen in the presence of sulfur dioxide, whereby the methane sulfonyl halide is obtained for isolation or further reactions. The further reactions may sequentially include, in order, contacting the methane sulfonyl halide with a catalyst complex to form a methane monohalide; catalytically converting the methane monohalide to a value-added chemical such as an alcohol, an olefin, an aromatic, derivatives thereof, or mixtures thereof; releasing any hydrogen halide formed in the process; and converting the hydrogen halide to a halogen and recycling it for re-use.

BIODEGRADABLE POLYETHYLENE GLYCOL DERIVATIVE HAVING CYCLIC BENZYLIDENE ACETAL LINKER

-

, (2018/04/14)

A biodegradable polyethylene glycol derivative in which a polyethylene glycol chain is linked by an acetal linker capable of accurately controlling the hydrolysis rate under different pH environments in the living body, and whose division rate into a polyethylene glycol chain of low molecular weight in the living body can be accurately controlled. The biodegradable polyethylene glycol derivative is represented by formula (1) or formula (2) as described.

Process route upstream and downstream products

Process route

dichloromethane
75-09-2

dichloromethane

chloroform
67-66-3,8013-54-5

chloroform

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With sulfur dioxide; chlorine; at 65 ℃; for 1h; under 2250.23 Torr; Temperature; Irradiation;
54.9%
chloroform
67-66-3,8013-54-5

chloroform

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With sulfur dioxide; chlorine; at 25 ℃; for 1h; under 2250.23 Torr; Temperature; Irradiation;
43.3%
tetrachloromethane
56-23-5

tetrachloromethane

methylene chloride
74-87-3

methylene chloride

dichloromethane
75-09-2

dichloromethane

chloroform
67-66-3,8013-54-5

chloroform

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With hydrogenchloride; sulfur dioxide; chlorine; at 63 - 67 ℃; under 6750.68 Torr; Photolysis;
55%
dimethyl sulfoxide
67-68-5,8070-53-9

dimethyl sulfoxide

methanethiosulfonic acid S-methyl ester
2949-92-0,31761-75-8

methanethiosulfonic acid S-methyl ester

dimethylsulfone
67-71-0

dimethylsulfone

hydrochloric acid, dimethyl sulphoxide
26394-12-7

hydrochloric acid, dimethyl sulphoxide

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With chlorine; In dichloromethane; at -0.1 ℃;
With chlorine; In dichloromethane; at -0.1 ℃; Further byproducts given;
S-methyl thioformate
27798-35-2

S-methyl thioformate

methanol
67-56-1

methanol

formic acid
64-18-6

formic acid

Methanesulfenyl chloride
5813-48-9

Methanesulfenyl chloride

formyl chloride
2565-30-2

formyl chloride

methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With chlorine; at 24.9 ℃; under 750.06 Torr; Product distribution; Irradiation; rate coefficients; also in the presence of air instead of N2; other time;
dichloromethane
75-09-2

dichloromethane

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With sulfur dioxide; chlorine; at 25 ℃; for 1h; under 2250.23 Torr; Concentration; Wavelength; Irradiation;
69%
Dimethyldisulphide
624-92-0

Dimethyldisulphide

methanethiosulfonic acid S-methyl ester
2949-92-0,31761-75-8

methanethiosulfonic acid S-methyl ester

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With water; sodium chloride; In tert-butyl methyl ether; at 25 ℃; for 0.25h; Electrochemical reaction;
methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

methanethiosulfonic acid S-methyl ester
2949-92-0,31761-75-8

methanethiosulfonic acid S-methyl ester

dimethylsulfide
75-18-3

dimethylsulfide

S-(chloromethyl) methanesulphonothioate
22224-96-0

S-(chloromethyl) methanesulphonothioate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
triethylamine; In diethyl ether; at 22 - 24 ℃; for 24h; Product distribution; other amines;
27 % Spectr.
3 % Spectr.
6 % Spectr.
5 % Spectr.
methylsulphinyl chloride
676-85-7

methylsulphinyl chloride

methanethiosulfonic acid S-methyl ester
2949-92-0,31761-75-8

methanethiosulfonic acid S-methyl ester

dimethylsulfide
75-18-3

dimethylsulfide

S-methyl methanethiosulfinate
13882-12-7

S-methyl methanethiosulfinate

methyl methanesulfinyl sulfone
14128-56-4

methyl methanesulfinyl sulfone

Zinc methanesulfinate
19186-23-3

Zinc methanesulfinate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With zinc; In various solvent(s); at -30 ℃; for 1.5h; Mechanism; Product distribution; var. solv., var. time, var. temp.;
7 % Spectr.
5 % Spectr.
9 % Spectr.
1 % Spectr.
3 % Spectr.
1 % Spectr.
S-Methylisothiourea sulfate
867-44-7,147895-43-0

S-Methylisothiourea sulfate

methanesulfonyl chloride
124-63-0

methanesulfonyl chloride

Conditions
Conditions Yield
With tert-butylhypochlorite; In water; acetonitrile; at 0 - 20 ℃;
79%
In diethyl ether; water; at 0 - 20 ℃; for 0.5h; Green chemistry;
0.808 g

Global suppliers and manufacturers

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.
close
Remarks: The blank with*must be completed