124083-42-7

Basic information

• Product Name: 5-(p-tolyl)-2H-pyrazol-3-ol
• Synonyms: 124083-42-7; 1H-pyrazol-5-ol, 3-(4-methylphenyl)-; 5-(p-tolyl)-1H-pyrazol-3(2H)-one
• CAS NO: 124083-42-7
• Molecular Formula: C₁₀H₁₀N₂O
• Molecular Weight: 174.1992
• Mol File: 124083-42-7.mol

Chemical Properties

• Boiling Point: 432.2°C at 760 mmHg
• Flash Point: 215.2°C
• Density: 1.235g/cm³
• Vapor Pressure: 4.47E-08mmHg at 25°C
• Refractive Index: 1.628
• CAS DataBase Reference: 5-(p-tolyl)-2H-pyrazol-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(p-tolyl)-2H-pyrazol-3-ol(124083-42-7)
• EPA Substance Registry System: 5-(p-tolyl)-2H-pyrazol-3-ol(124083-42-7)

Safety Data

• Hazardous Substances Data: 124083-42-7(Hazardous Substances Data)

Upstream product

• 52188-06-4 ethyl 3-(4-methylphenyl)prop-2-ynoate 
• 1034378-87-4 Z-ethyl 2-(hydroxy(p-tolyl)methylene)-3-oxobutanoate 

Downstream Products

• 7515-16-4 methyl 3-(4-methylphenyl)prop-2-ynoate 

Relevant articles and documents

A rare γ-pyranopyrazole skeleton: Design, one-pot synthesis and computational study

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straightforward synthetic route has been developed for a range of pyrazole fused γ-pyrone derivatives. The reaction mechanism proposed for the chemoselective form

Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS, and p53 levels in vascular endothelial cells

Recently, pyrazole derivatives as high affinity and selective A2A adenosine receptor antagonists have been reported. But, so far, there are no reports about the inhibitory effects of multi-substituted pyrazole derivatives on apoptosis of vascular endothelial cells (VECs). In this study, we synthesized six pyrazole derivatives and characterized the structures of the compounds by IR, 1H NMR, mass spectroscopy, and element analysis. The biology assay showed that a novel pyrazole derivative, ethyl 3-(o-chlorophenyl)-5-methyl-1-phenyl-1H-pyrazole-4-carboxylate (MPD) at low concentration (25 μM) increased VECs viability and inhibited VECs apoptosis induced by deprivation of serum and FGF-2. During this process, the levels of integrin β4, reactive oxygen species (ROS), and p53 were depressed obviously. The data suggested that MPD was a potential inhibitor of apoptosis associated with the signal pathway mediated by integrin β4, ROS, and p53 in VECs.