124170-23-6Relevant articles and documents
Cross cage interactions in substituted bicyclo[1.1.]pent-1-yl radicals. Dissociation to [1.1.1]propellane
Adcock, William,Binmore, Gavin T.,Krstic, Alexander R.,Walton, John C.,Wilkie, John
, p. 2758 - 2766 (2007/10/02)
A series of 3-substituted bicyclo[1.1.1]pent-1-yl radicals, including the 3-fluoro derivative, was generated by bromine atom abstraction from 1-bromo-3-substituted-bicyclo[1.1.1]pentanes and examined by EPR spectroscopy. The exceptionally large hyperfine splittings obtained from magnetic nuclei of the 3-substituents indicated that cross cage electronic interactions were substantial in these species. Bromine atom abstraction by triethylsilyl radicals from 1-bromo-3-fluorobicyclo[1.1.1]pentane was found to take place more rapidly than bromine abstraction from the unsubstituted parent, i. e., the fluorine substituent mediated a significant polar effect. Evidence was found of a novel disproportionation process in which the γ-fluorine atom was transferred from the 3-fluoro radical to a triethylsilyl or to a second bicyclo[1.1.1]pent-1-yl radical; an analogous chlorine atom transfer process was found for the 3-chloro radical. Ab initio MO calculations (6-31G* basis with electron correlation up to MP4) on the 3-fluoro- and 3-methyl-substituted radicals indicated that loss of the substituent to give [1.1.1]propellane would be comparatively easy for both species.
New Fluorinating Reagents. Part II. Preparation and Synthetic Application of a Saccharin Derived N-Fluorosultam
Differding, Edmond,Lang, Robert W.
, p. 1248 - 1252 (2007/10/02)
The synthesis of the new saccharin derived N-fluorosultam 1 is described.A comparative study with commercially available N-fluorosulfonamides shows 1 to be a superior fluorinating reagent for the synthesis of α-fluorocarbonyl compounds.
