1242099-11-1

Basic information

• Product Name: C₈H₈O₃*C₂₂H₁₉N₃O₄
• CAS NO: 1242099-11-1
• Molecular Weight: 541.56
• Mol File: 1242099-11-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: C₈H₈O₃*C₂₂H₁₉N₃O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₈H₈O₃*C₂₂H₁₉N₃O₄(1242099-11-1)
• EPA Substance Registry System: C₈H₈O₃*C₂₂H₁₉N₃O₄(1242099-11-1)

Safety Data

• Hazardous Substances Data: 1242099-11-1(Hazardous Substances Data)

Upstream product

• 99-76-3 methyl 4-hydroxylbenzoate 
• 171596-29-5 (6R,12aR)-2,3,6,7,12,12a-hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)-pyrazino[2',1':6,1]pyrido[3,4-b]indole-1,4-dione 

Relevant articles and documents

The effect of surfactant and polymer on solution stability and solubility of tadalafil-methylparaben cocrystal

Cocrystal formation is a novel method to enhance physicochemical properties of pharmaceuticals. However, instability in solution is one of the challenging issues of cocrystals and surfactants/polymers could have a positive effect on cocrystal solubility and stability. In this study, tadalafil cocrystal was prepared via the solvent drop grinding method with methylparaben as a cocrystal former. The thermodynamic solubility of cocrystal was determined in phosphate buffer solution (pH = 6.8) and in the presence of different concentrations of sodium lauryl sulfate (SLS) and polyvinylpyrrolidone (PVP), followed by investigating their effects on solution stability of cocrystal. The prepared cocrystal showed enhancement in solubility compared with tadalafil, but the solution stability analysis indicated it is an incongruently saturating cocrystal that could transform to a less soluble solid form during slurring and dissolution. Moreover, PVP and SLS improved the cocrystal solution stability, however, the solubility advantage for the prepared cocrystal is not obtained because of preferential solubilization for tadalafil that is less soluble than methylparaben. Overall, the results showed that cocrystal formation of tadalafil with methylparaben has the ability to change its physicochemical properties. In addition, polymer and surfactant could have a significant effect on the solubility and the stability of the cocrystal.

CRYSTALIZATION OF PHARMACEUTICAL COMPOUNDS

Novel crystalline forms of tadalafil suitable for pharmaceutical compositions in drug delivery systems for humans.