124211-72-9Relevant articles and documents
A simple method for the preparation of aryl trifluoromethyl ketones
Simchen, Gerhard,Schmidt, Andreas
, p. 1093 - 1094 (1996)
4-Dimethylamino-1-trifluoroacetylpyridinium trifluoroacetate (2) is an effective, easy to handle and stable trifluoroacetylation agent. Aryl trifluormethyl ketones 4 are obtained in good yields by reaction of 2 with aromatic compounds 3 in the presence of aluminum chloride.
M -Azipropofol (AziP m) a photoactive analogue of the intravenous general anesthetic propofol
Hall, Michael A.,Xi, Jin,Lor, Chong,Dai, Shuiping,Pearce, Robert,Dailey, William P.,Eckenhoff, Roderic G.
experimental part, p. 5667 - 5675 (2010/11/04)
Propofol is the most commonly used sedative-hypnotic drug for noxious procedures, yet the molecular targets underlying either its beneficial or toxic effects remain uncertain. In order to determine targets and thereby mechanisms of propofol, we have synthesized a photoactivateable analogue by substituting an alkyldiazirinyl moiety for one of the isopropyl arms but in the meta position. m-Azipropofol retains the physical, biochemical, GABAA receptor modulatory, and in vivo activity of propofol and photoadducts to amino acid residues in known propofol binding sites in natural proteins. Using either mass spectrometry or radiolabeling, this reagent may be used to reveal sites and targets that underlie the mechanism of both the desirable and undesirable actions of this important clinical compound.
A Convenient Trifluoroacetylation of Arenes with 2-(Trifluoroacetoxy)pyridine
Keumi, Takashi,Shimada, Masakazu,Takahashi, Masahiro,Kitajima, Hidehiko
, p. 783 - 786 (2007/10/02)
2-(Trifluoroacetoxy)pyridine (TFAP) is useful for trifluoroacetylating arenes under Friedel-Crafts conditions.Benzene, alkylbenzenes, naphthalene, and dibenzofuran have reacted with TFAP in the presence of aluminum chloride in dichloromethane to give the corresponding trifluoromethyl aryl ketones in good isolated yields.