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1242658-50-9

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1242658-50-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1242658-50-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,4,2,6,5 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1242658-50:
(9*1)+(8*2)+(7*4)+(6*2)+(5*6)+(4*5)+(3*8)+(2*5)+(1*0)=149
149 % 10 = 9
So 1242658-50-9 is a valid CAS Registry Number.

1242658-50-9Downstream Products

1242658-50-9Relevant articles and documents

Investigations on the 2-thiazolylhydrazyne scaffold: Synthesis and molecular modeling of selective human monoamine oxidase inhibitors

Chimenti, Franco,Bolasco, Adriana,Secci, Daniela,Chimenti, Paola,Granese, Arianna,Carradori, Simone,Yanez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano

experimental part, p. 5715 - 5723 (2010/09/09)

A new series of [4-(3-methoxyphenyl)-thiazol-2-yl]hydrazyne derivatives were synthesized in good yield (71-99%) and characterized by elemental analysis and 1H NMR studies. The compounds were assayed for their in vitro human monoamine oxidase (hMAO) inhibitory activity and selectivity and most of them showed IC50 values in the nanomolar range, thus demonstrating our interest in this privileged scaffold. The most active and selective derivative (20), bearing a pyridine moiety on the CN, displayed IC50 = 3.81 ± 0.12 nM and selectivity ratio = 119 toward hMAO-B. Molecular modeling studies were carried out on recent and high resolution hMAO-A and hMAO-B crystallographic structures to better justify the enzyme-inhibitor interaction toward hMAO isoforms and to explain the structure-activity relationship of this kind of inhibitors.

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