124899-25-8Relevant articles and documents
Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy
Riggs, Jennifer R.,Elsner, Jan,Cashion, Dan,Robinson, Dale,Tehrani, Lida,Nagy, Mark,Fultz, Kimberly E.,Krishna Narla, Rama,Peng, Xiaohui,Tran, Tam,Kulkarni, Ashutosh,Bahmanyar, Sogole,Condroski, Kevin,Pagarigan, Barbra,Fenalti, Gustavo,Lebrun, Laurie,Leftheris, Katerina,Zhu, Dan,Boylan, John F.
supporting information, p. 4401 - 4410 (2019/05/17)
Triple negative breast cancer (TNBC) is an aggressive disease with high relapse rates and few treatment options. Outlined in previous publications, we identified a series of potent, dual TTK/CLK2 inhibitors with strong efficacy in TNBC xenograft models. P
SULFUR YLIDES IN REACTIONS WITH 4-SUBSTITUTED CYCLOHEXANONES: STEREOCHEMISTRY AND REACTIVITY
Migneco, Luisa M.,Vecchi, Elisabetta
, p. 19 - 24 (2007/10/03)
The stereochemistry of the epoxidation reactions of the title compounds (R= Me, Et, t-Bu, Ph, p-F-Ph, OMe, OH, CF3, OCOPh) with sulfur ylides (dimethylsulfonium methylide and dimethyloxosulfonium methylide) has been determined in three different solvents (DMSO, C6H6 and THF).Relative rates have been measured and the kinetic constants kcis and ktrans determined.