Welcome to LookChem.com Sign In|Join Free

CAS

  • or

124953-49-7

Post Buying Request

124953-49-7 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

124953-49-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 124953-49-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,9,5 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 124953-49:
(8*1)+(7*2)+(6*4)+(5*9)+(4*5)+(3*3)+(2*4)+(1*9)=137
137 % 10 = 7
So 124953-49-7 is a valid CAS Registry Number.

124953-49-7Downstream Products

124953-49-7Relevant articles and documents

New isoxazole derivatives provided with antihypertensive activity

Carenzi,Chiarino,Napoletano,Reggiani,Sala,Sala

, p. 642 - 646 (2007/10/02)

A series of diazacycloalkane-quinazoline derivatives of isoxazoles were synthesized and tested in order to identify new potent and selective α1-antagonists. A preliminary screening by using in vitro tests such as binding assay (3H-prazosin and 3H-rauwolscine displacement) and analysis of antagonistic activity in isolated rat aorta (norepinephrine-induced response) and in isolated rat vas deferens (clonidine-induced response) indicated that many of these compounds exhibited a good affinity and selectivity towards α1-adrenergic receptors associated with potent pharmacological activity. In particular, a 3-bromo-5-isoxazolecarbonyl derivative, selected for further in vivo investigation, was provided with as high antihypertensive action as prazosin in spontaneously hypertensive rats (SHR) coupled to a shallow dose-response curve by route. Moreover, a higher ratio between oral antihypertensive dosis in SHR and normotensive rats was found with respect to reference compound prazosin.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 124953-49-7