125035-83-8

Basic information

• Product Name: 7-Oxo Staurosporine
• Synonyms: (9S,10R,11R,13R)-10,11,12,13-Tetrahydro-10-Methoxy-9-Methyl-11-(MethylaMino)- 9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lM]pyrrolo[3,4-j][1,7]benzodiazonine-1,3(2H)-dione;BMY 41950;RK 1409;7-Oxo Staurosporin
• CAS NO: 125035-83-8
• Molecular Formula: C28H24N4O4
• Molecular Weight: 480.51456
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Protein Kinase Inhibitors and Activators
• Mol File: 125035-83-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-Oxo Staurosporine(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Oxo Staurosporine(125035-83-8)
• EPA Substance Registry System: 7-Oxo Staurosporine(125035-83-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 125035-83-8(Hazardous Substances Data)

Usage

Uses

A metabolite of Staurosporine (S685000).

Upstream product

• 62996-74-1 staurosporine 
• 174291-03-3 3'-O,4'-N-carbonyl-3'-O-desmethyl-4'-N-desmethyl-ent-7-oxostaurosporine 
• 174291-02-2 3'-O,4'-N-carbonyl-3'-O-desmethyl-4'-N-desmethyl-6-N,4'-N-bis<(benzyloxy)methyl>-ent-7-oxostaurosporine 
• 174291-05-5 6-N-<(benzyloxy)methyl>-3'-O,4'-N-carbonyl-3'-O-desmethyl-4'-N-desmethyl-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine 
• 174148-74-4 6-N-<(benzyloxy)methyl>-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine 
• 174291-06-6 6-N-<(benzyloxy)methyl>-3'-O-desmethyl-4'-N-desmethyl-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine 
• 174291-04-4 3'-O,4'-N-carbonyl-3'-O-desmethyl-4'-N-desmethyl-ent-7-oxo-4'-N-(tert-butyloxycarbonyl)staurosporine 

Relevant articles and documents

Bisindolyl maleimide derivative and preparation method and application thereof

The invention provides a bisindolyl maleimide derivative and a preparation method and application thereof. The bisindolyl maleimide derivative has an excellent alpha-glucosidase inhibition effect and can be used for preventing and treating diabetes.

Staurosporine and ent-staurosporine: The first total syntheses, prospects for a regioselective approach, and activity profiles

The total syntheses of staurosporine and ent-staurosporine have been achieved. Both glycosidic bonds were built from glycal precursors. The first was constructed by intermolecular coupling of an indole anion with a 1,2-anhydrosugar derived from an endo-glycal by direct epoxidation. The second bond was assembled from an exo-glycal by intramolecular iodoglycosylation.