125161-13-9Relevant articles and documents
Design, synthesis and evaluation of small molecule imidazo[2,1-b][1,3,4]thiadiazoles as inhibitors of transforming growth factor-β type-I receptor kinase (ALK5)
Patel, Harun M.,Sing, Baljeet,Bhardwaj, Varun,Palkar, Mahesh,Shaikh, Mahamadhanif S.,Rane, Rajesh,Alwan, Wesam S.,Gadad, Andanappa K.,Noolvi, Malleshappa N.,Karpoormath, Rajshekhar
, p. 599 - 613 (2015/03/18)
A new series of imidazo[2,1-b][1,3,4]thiadiazoles 5(a-g), 6(a-g), 9(a-i) and 12(a-h) were synthesized as transforming growth factor-β (TGF-β) type I receptor (also known as activin receptor-like kinase 5 or ALK5) inhibitors. These compounds were evaluated
Heterocyclic systems containing bridgehead nitrogen atom: Reactions of 2-aminothiadiazoles with α-haloketones and ketones in presence of NBS
Mohan, Jag,Anjaneyulu, G. S. R.,Kiran
, p. 500 - 502 (2007/10/02)
Synthesis of 2,6-Diarylimidazo-1,3,4-thiadiazoles (III) have been achieved by the reaction of α-haloketones with 2-aminothiadiazoles (II) or more conveniently by treating II directly with ketones in the presence of NBS.Bromination of III furnishes