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1254058-34-8

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1254058-34-8 Usage

General Description

3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline is a chemical compound with the molecular formula C20H32N4O. It is a derivative of aniline and contains a methoxy group, as well as piperazine and piperidine rings. 3-Methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline is commonly used in pharmaceutical research and may have potential applications in drug development. Its structural features and functional groups suggest that it may have biological activity and may interact with various protein targets in the body. Further research is needed to fully understand the potential uses and effects of this chemical.

Check Digit Verification of cas no

The CAS Registry Mumber 1254058-34-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,4,0,5 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1254058-34:
(9*1)+(8*2)+(7*5)+(6*4)+(5*0)+(4*5)+(3*8)+(2*3)+(1*4)=138
138 % 10 = 8
So 1254058-34-8 is a valid CAS Registry Number.

1254058-34-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]aniline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1254058-34-8 SDS

1254058-34-8Relevant articles and documents

SUBSTITUTED DIAMINO HETEROCYCLIC CARBOXAMIDE COMPOUND AND A COMPOSITION CONTAINING THE COMPOUND AND USE THEREOF

-

, (2020/12/07)

A substituted amino heterocyclic carboxamide compound as represent by formula (Φ), or a pharmaceutically acceptable salt, a prodrug, a hydrate or a solvent compound, a crystal form, a stereoisomer or an isotopic variant of the compound, and a pharmaceutical composition thereof, and the use thereof as an FLT3/AXL kinase inhibitor for treating acute myelocytic leukemia.

Discovery of N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N′-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a potent and selective anaplastic lymphoma kinase (ALK) inhibitor

Iikubo, Kazuhiko,Kondoh, Yutaka,Shimada, Itsuro,Matsuya, Takahiro,Mori, Kenichi,Ueno, Yoko,Okada, Minoru

, p. 251 - 262 (2018/03/13)

Anaplastic lymphoma kinase (ALK) is a validated therapeutic target for treating echinoderm microtubule- associated protein-like 4 (EML4)-ALK positive non-small cell lung cancer (NSCLC). We synthesized a series of 1,3,5-triazine derivatives and identified ASP3026 (14a) as a potent and selective ALK inhibitor. In mice xenografted with NCI-H2228 cells expressing EML4-ALK, once-daily oral administration of 14a demonstrated dose-dependent antitumor activity. Here, syntheses and structure-activity relationship (SAR) studies of 1,3,5-triazine derivatives are described.

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