Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1255791-52-6

Post Buying Request

1255791-52-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

1255791-52-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1255791-52-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,5,7,9 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1255791-52:
(9*1)+(8*2)+(7*5)+(6*5)+(5*7)+(4*9)+(3*1)+(2*5)+(1*2)=176
176 % 10 = 6
So 1255791-52-6 is a valid CAS Registry Number.

1255791-52-6Downstream Products

1255791-52-6Relevant articles and documents

Design, synthesis, X-ray studies, and biological evaluation of novel macrocyclic HIV-1 protease inhibitors involving the P1′-P2′ ligands

Ghosh, Arun K.,Sean Fyvie,Brindisi, Margherita,Steffey, Melinda,Agniswamy, Johnson,Wang, Yuan-Fang,Aoki, Manabu,Amano, Masayuki,Weber, Irene T.,Mitsuya, Hiroaki

, p. 4925 - 4931 (2018/02/09)

Design, synthesis, and evaluation of a new class of HIV-1 protease inhibitors containing diverse flexible macrocyclic P1′-P2′ tethers are reported. Inhibitor 5a with a pyrrolidinone-derived macrocycle exhibited favorable enzyme inhibitory and antiviral activity (Ki = 13.2 nM, IC50 = 22 nM). Further incorporation of heteroatoms in the macrocyclic skeleton provided macrocyclic inhibitors 5m and 5o. These compounds showed excellent HIV-1 protease inhibitory (Ki = 62 pM and 14 pM, respectively) and antiviral activity (IC50 = 5.3 nM and 2.0 nM, respectively). Inhibitor 5o also remained highly potent against a DRV-resistant HIV-1 variant.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1255791-52-6