1256752-41-6

Basic information

• Product Name: [3-[1-(benzenesulfonyl)indol-3-yl]allyl] 3-(4-methoxyphenyl)prop-2-ynoate
• Synonyms: [3-[1-(benzenesulfonyl)indol-3-yl]allyl] 3-(4-methoxyphenyl)prop-2-ynoate
• CAS NO: 1256752-41-6
• Molecular Weight: 471.533
• Mol File: 1256752-41-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: [3-[1-(benzenesulfonyl)indol-3-yl]allyl] 3-(4-methoxyphenyl)prop-2-ynoate(CAS DataBase Reference)
• NIST Chemistry Reference: [3-[1-(benzenesulfonyl)indol-3-yl]allyl] 3-(4-methoxyphenyl)prop-2-ynoate(1256752-41-6)
• EPA Substance Registry System: [3-[1-(benzenesulfonyl)indol-3-yl]allyl] 3-(4-methoxyphenyl)prop-2-ynoate(1256752-41-6)

Safety Data

• Hazardous Substances Data: 1256752-41-6(Hazardous Substances Data)

Upstream product

• 2227-57-8 3-(4-methoxyphenyl)propynoic acid 
• 1022988-04-0 1-benzenesulphonyl-3-(3-chloroprop-1-en-1-yl)-1H-indole 

Downstream Products

• 1256752-46-1 4-(4-methoxyphenyl)-5-benzenesulphonyl-1H-furo[3,4-b]carbazol-3(3H,5H,10H)-one 
• 1256752-51-8 5-benzenesulphonyl-4-(4-methoxyphenyl)-1,5-dihydro-3H-furo[3,4-b]carbazol-3-one 

Relevant articles and documents

Synthesis and biological activities of new furo[3,4-b]carbazoles: Potential topoisomerase II inhibitors

New 1,5-Dihydro-4-(substituted phenyl)-3H-furo[3,4-b]carbazol-3-ones were synthesised via a key step Diels-Alder reaction under microwave irradiation. 3-Formylindole was successfully used in a 6-step synthesis to obtain those complex heterocycles. The Diels-Alder reaction generating the carbazole ring was optimised under thermal conditions or microwave irradiation. After cleavage of functional groups, DNA binding, topoisomerase inhibition and cytotoxic properties of the new-formed furocarbazoles were investigated. These carbazoles do not present a strong interaction with the DNA, and do not modify the relaxation of the DNA in the presence of topoisomerase I or II except for one promising compound. This compound is a potent topoisomerase II inhibitor, and its cellular activity is not moderated compared to etoposide. The synthesis of these molecules allowed the generalisation of the method using indole and 5-OBn indole and several benzaldehydes. The synthesis of these molecules produced chemical structures endowed with promising cytotoxic and topoisomerase II inhibition activities.