1258503-57-9

Basic information

• Product Name: C₄₃H₂₅NO₂
• CAS NO: 1258503-57-9
• Molecular Weight: 587.677
• Mol File: 1258503-57-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₃H₂₅NO₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₃H₂₅NO₂(1258503-57-9)
• EPA Substance Registry System: C₄₃H₂₅NO₂(1258503-57-9)

Safety Data

• Hazardous Substances Data: 1258503-57-9(Hazardous Substances Data)

Upstream product

• 91026-00-5 N-benzyl-2,3-dibromo-maleimide 
• 164461-18-1 1-pyrenylboronic acid 

Relevant articles and documents

The spermine-bisaryl conjugate as a potent inducer of B- to Z-DNA transition

DNA containing alternating purine and pyrimidine repeats has the potential to adopt the Z-DNA structure, one of the well-studied structures besides A- and B-DNA. Despite a number of molecular models that have been proposed to explain the mechanism for B→Z transition, there is continued discussion on the mechanism and physiological role of this transition. In this study, we have found that the bis(2-naphthyl)-maleimide-spermine conjugate (3c) exhibits a remarkable ability to cause the B→Z transition of d(CGCGCG)2 at low salt concentrations. Using isothermal titration calorimetry (ITC) we show that the B→Z transition induced by 3c is both enthalpically and entropically favorable. The ligand might effect the dehydration of B-DNA, which leads to the B→Z transition. Interestingly, an intermediate CD between the B and Z forms was observed in the pH-dependent transition in the presence of the ligand. The unique structure and characteristics of the ligand designed in this investigation will be useful for the study of Z-DNA. From B to Z: The bis(2-naphthyl)maleimide-spermine conjugate shown in the figure exhibits a remarkable ability to cause the B→Z transition of d(CGCGCG)2 at low salt concentrations. A stable intermediate between the B and Z forms was observed in the presence of the ligand at about pH 8.