1258507-69-5Relevant articles and documents
New chiral ligands: 1,4-diols prepared from (S)-1-phenylethanol
Shishkina,Sokolovskaya,Potekhin,Nelyubina,Askerov,Dem'Yanovich
experimental part, p. 1332 - 1338 (2011/01/04)
The stereochemistry of condensation of dilithiated 1-phenylethanol with various carbonyl compounds was investigated. In most cases the reaction proceeds nonstreoselectively, and only in the condensation with PhCOBu-t and 2,4-(MeO)2C6H3COPh only one of the diastereomeric diols prevailed. It was shown by XRD analysis that in the prevailing diastereomeric diol the newly formed chiral carbinol center possessed the same configuration as the initial alcohol. The synthesized diols form homochiral dimers in the crystal lattice.