1258946-38-1

Basic information

• Product Name: tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate
• Synonyms: tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate
• CAS NO: 1258946-38-1
• Molecular Weight: 619.845
• Mol File: 1258946-38-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate(1258946-38-1)
• EPA Substance Registry System: tert-butyl 2-{[(4-aminophenyl)methyl](2-{4,7-bis[2-(tert-butoxy)-2-oxoethyl]-1,4,7-triazonan-1-yl}ethyl)amino}acetate(1258946-38-1)

Safety Data

• Hazardous Substances Data: 1258946-38-1(Hazardous Substances Data)

Upstream product

• 1016237-77-6 t-butyl [(2-bromo-ethyl)-(4-nitro-benzyl)-amino]acetate 
• 64834-64-6 2-(4-nitrobenzylbenzylamino)ethanol 
• 555-16-8 4-nitrobenzaldehdye 
• 1016237-79-8 t-butyl (4-tert-butoxycarbonylmethyl-7-{2-[tert-butoxycarbonylmethyl-(4-nitro-benzyl)-amino]ethyl}-[1,4,7]triazonan-1-yl)acetate 
• 1016237-75-4 t-butyl [(2-hydroxy-ethyl)-(4-nitro-benzyl)-amino]acetate 

Relevant articles and documents

Novel 64Cu-radiolabeled bile acid conjugates for targeted PET imaging

A promising bifunctional chelate (N-NE3TA) was conjugated to bile acids, cholic acid (CA), deoxycholic acid (DCA), and chenodeoxycholic acid (CDCA) as tumor targeting vectors. Bile acid conjugates of N-NE3TA (CA-N-NE3TA, DCA-N-NE3TA, and CDCA-N-NE3TA) were comparatively evaluated for complexation with 64Cu, an imaging probe for positron emission tomography (PET). N-NE3TA-bile acid conjugates were evaluated for radiolabeling kinetics with 64Cu, and the corresponding 64Cu-radiolabeled conjugates were screened for complex stability in human serum and EDTA solution. The NE3TA-bile acid conjugates instantly bound to 64Cu with excellent radiolabeling efficiency at room temperature. All NE3TA-bile acid conjugates radiolabeled with 64Cu remained inert in human serum for 2 days without releasing a considerable amount of the radioactivity. The 64Cu-radiolabeled complexes were further challenged by EDTA in a 100-fold molar excess. Bile acid-N-NE3TA conjugates radiolabeled with 64Cu were quite stable with a minimal transfer of 64Cu to EDTA at 4 h time point. The in vitro data indicate that the bile acid-N-NE3TA conjugates deserve further biological evaluation for 64Cu-based targeted PET imaging applications.

Bimodal ligands with macrocyclic and acyclic binding moieties, complexes and compositions thereof, and methods of using

Substituted 1,4,7-triazacyclononane-N,N′,N″-triacetic acid and 1,4,7,10-tetraazacyclcododecane-N,N′,N″,N′″-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.