125914-22-9

Basic information

• Product Name: 2-(5-bromo-2-nitrophenyl)acetonitrile
• Synonyms: 2-(5-bromo-2-nitrophenyl)acetonitrile
• CAS NO: 125914-22-9
• Molecular Formula: C₈H₅BrN₂O₂
• Molecular Weight: 241.0415
• Mol File: 125914-22-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(5-bromo-2-nitrophenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-bromo-2-nitrophenyl)acetonitrile(125914-22-9)
• EPA Substance Registry System: 2-(5-bromo-2-nitrophenyl)acetonitrile(125914-22-9)

Safety Data

• Hazardous Substances Data: 125914-22-9(Hazardous Substances Data)

Usage

General Description

2-(5-bromo-2-nitrophenyl)acetonitrile is a chemical compound with the molecular formula C8H5BrN2O2. It is a yellow solid and is often used as an intermediate in the synthesis of various organic compounds. 2-(5-bromo-2-nitrophenyl)acetonitrile is known for its role in the production of pharmaceuticals and agrochemicals. It is also used in research and development and in the manufacturing of specialty chemicals. 2-(5-bromo-2-nitrophenyl)acetonitrile is a versatile building block in organic chemistry and is used as a starting material for the synthesis of a wide range of compounds with diverse applications.

Upstream product

• 31938-07-5 (3-bromophenyl)acetonitrile 
• 3598-13-8 (4-chlorophenoxy)acetonitrile 
• 586-78-7 para-nitrophenyl bromide 

Downstream Products

• 1259405-82-7 (5-bromo-2-nitrophenyl)(1-methylpyrrolidin-2-ylidene)acetonitrile 
• 882855-95-0 2-(2-amino-5-bromophenyl)acetonitrile 
• 147689-02-9 (Z)-2-(5-Bromo-2-nitro-phenyl)-but-2-enenitrile 
• 153887-97-9 2-(5-Bromo-2-nitro-phenyl)-pent-4-enenitrile 
• 10075-48-6 5-bromo-3-methyl-1H-indole 
• 10075-50-0 5-bromo-1H-indole 
• 120-72-9 indole 
• 124840-61-5 2-(5-bromo-2-nitrophenyl)aceticacid 

Relevant articles and documents

Modular Synthesis of Polysubstituted Quinolin-3-amines by Oxidative Cyclization of 2-(2-Isocyanophenyl)acetonitriles with Organoboron Reagents

Polysubstituted quinolin-3-amines are vital structural motifs because of their broad biological activities as well as versatile transformational abilities. However, they are not easily accessible. We disclose a protocol with Mn(III) acetate as a mild one-

Novel synthesis of benzofuran- and indol-2-yl-methanamine derivatives

We report on a novel synthesis towards benzofuran-2-yl-methanamine and indol-2-yl-methanamine derivatives by using ortho-methoxy and ortho-nitro substituted phenylacetic acids as starting material, respectively. For each compound series, a key intermediate bearing the oxazole-4-carboxylic acid methylester moiety was produced. Refluxing the ortho-methoxy series in HBr/HAc produced the desired benzofuran-2-yl-methanamines. Accordingly, for the synthesis of indoles the nitro-group was first reduced and refluxing these intermediates in HCl gave the corresponding indol-2-yl-methanamines. The method worked well with electron donating substituents. Limitations regarding electron withdrawing substituents are discussed. This straightforward synthetic procedure can be a useful approach to generate a variety of substituted benzofuran-2-yl-methanamine and indol-2-yl-methanamine compounds by starting from readily available phenylacetic acid derivatives.

Synthesis of Tiliacora alkaloids. III: Synthesis of biaryls by the Ullmann reaction

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