1260145-38-7Relevant articles and documents
A concise and straightforward approach to total synthesis of (+)-Strictifolione and formal synthesis of Cryptofolione via a unified strategy
Li, Xiaotong,Wang, Gaopeng,Zhang, Zhibin,Wu, Na,Yang, Qianqian,Huang, Shuangping,Wang, Xiaoji
, p. 1031 - 1039 (2019)
We describe a concise and straightforward approach to the total syntheses of (+)-Strictifolione and Cryptofolione in the longest linear sequences of four steps and six steps from 3-phenyl propanal and trans-cinnamaldehyde, respectively. The route utilized a titanium tetraisopropoxide/(R)-[1,1'-binaphthalene]-2,2'-diol catalyzed Mukaiyama aldol reaction, indium(0)-promoted Barbier reaction, and olefin cross-metathesis as the key reactions.
Anti-trypanosome anticancer natural product Cryptofolione synthesizing method
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Paragraph 0024; 0029; 0030, (2018/10/11)
The invention discloses an anti-trypanosome anticancer natural product Cryptofolione synthesizing method. The synthesizing method disclosed by the invention comprises the steps: after acrolein and silyl enol ether are utilized to perform Mukaiyama aldol reaction, sodium borohydride is used for reducing ketone into alcohol, and then pyridinium p-toluenesulfonate refluxes in a methylbenzene solutionto obtain compound shown in a formula 5; after cinnamyl aldehyde and an evans chiral aid are used for performing evans aldol reaction, diisobutyl aluminum hydride is used for reducing the cinnamyl aldehyde and the evans chiral aid at first, and then addition with metal indium activated 3-propylene bromine is performed to obtain compound shown in a formula 9; the compound shown in the formula 9 isresolved and purified for many times by kinetic resolution; the compound shown in the formula 9 and 2,2-diemthoxy propane can obtain fragment type 10 compound under the pyridinium p-toluenesulfonatecondition, the fragment type 10 compound and fragment type 5 compound can generate olefin metathesis reaction through a Grubbs secondary catalyst, and protecting groups of the fragment type 10 compound are removed under the hydrochloric acid condition to obtain Cryptofolione.
Stereoselective total synthesis of (+)-cryptofolione and (+)-goniothalamin
Das, Biswanath,Nagendra, Siddavatam,Reddy, Cheruku Ravindra
, p. 1249 - 1254 (2011/10/19)
The stereoselective total synthesis of two naturally occurring α-pyrone derivatives (+)-cryptofolione and (+)-goniothalamin has been accomplished via a common intermediate. The synthetic sequence involves the asymmetric reduction of a propargyl ketone and olefin cross-metathesis as the key reactions.
