127053-48-9

Basic information

• Product Name: Methyl (2S,3R)-3-phenyl-1H-aziridine-2-carboxylate
• Synonyms: Methyl (2S,3R)-3-phenyl-1H-aziridine-2-carboxylate
• CAS NO: 127053-48-9
• Molecular Weight: 177.203
• Mol File: 127053-48-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Methyl (2S,3R)-3-phenyl-1H-aziridine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (2S,3R)-3-phenyl-1H-aziridine-2-carboxylate(127053-48-9)
• EPA Substance Registry System: Methyl (2S,3R)-3-phenyl-1H-aziridine-2-carboxylate(127053-48-9)

Safety Data

• Hazardous Substances Data: 127053-48-9(Hazardous Substances Data)

Upstream product

• 124994-14-5 cis-N-(p-tolylsulfonyl)-2-carbomethoxy-3-phenylaziridine 
• 121-39-1 ethyl 3-phenylglycidate 
• 100-52-7 benzaldehyde 
• 129939-41-9 Sodium (-)-(2R,3S)-E-3-phenyl oxirane-2-carboxylate 
• 98819-68-2 3-phenyl-(2R,3R)-oxiran-2-ylmethanol 
• 115794-67-7 methyl (2R,3S)-3-phenylglycidate 
• 104196-23-8 (2S,3S)-2,3-epoxy-3-phenyl-1-propanol 
• 252248-89-8 N-cinnamoylpyrrole[1-(pyrrol-1'-yl)-3-phenylprop-2E-enone] 
• 124-41-4 sodium methylate 
• 127127-36-0 cis-(4R,5R)-2,2,2,4-Tetraphenyl-5-methoxycarbonyl-1,3,2-oxazaphospholidine 
• 54885-10-8 sodium (E)-3-phenylglycidate 
• 19190-80-8 methyl trans-3-phenylglycidate 
• 6362-58-9 methyl phenylpyruvate 
• 500130-99-4 methyl (Z)-3-phenyl-2-trifluoromethylsulfonyloxy propenoate 

Downstream Products

• 127053-49-0 (2S,3R)-2-Amino-3-phenyl-3-phenylsulfanyl-propionic acid methyl ester 
• 127053-49-0 Methyl (2R,3S)-2-amino-3-phenyl-3-(phenylthio)propanoate 
• 105531-74-6 (+/-)-cis-2-hydroxymethyl-3-phenylaziridine 
• 19185-82-1 Methyl (2R^*,3S^*)-2-(acetylamino)-3-hydroxy-3-phenylpropanoate 
• 18709-45-0 methyl 3-phenyl-2H-azirine-2-carboxylate 
• 141241-06-7 Methyl (4R^*,5S^*)-2-methyl-5-phenyloxazoline-4-carboxylate 
• 163061-47-0 (S)-(+)-2-carbomethoxy-3-phenyl-2H-azirine 
• 141241-05-6 Methyl (2R^*,3S^*)-3-chloro-3-phenyl-2-(tosylamino)propanoate 
• 141241-04-5 Methyl 1-(benzyloxycarbonyl)-trans-3-phenylaziridine-2-carboxylate 
• 141317-11-5 Methyl (2S,3S)-2-(acetylamino)-3-hydroxy-3-phenylpropanoate 
• 19185-82-1 Methyl (2R^*,3R^*)-2-(acetylamino)-3-hydroxy-3-phenylpropanoate 
• 129939-58-8 (2S,3R)-1-(Biphenyl-4-carbonyl)-3-phenyl-aziridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Exploiting the chemistry of strained rings: Synthesis of indoles via domino reaction of aryl iodides with 2 H-azirines

(Equation Presented). The highly strained 2H-azirine ring system has been the source of considerable theoretical and synthetic work. The reaction of these strained heterocycles with transition metals has been documented to give rise to ring opening and subsequent formation of varied heterocycles. An interesting domino reaction is described wherein the strained bicyclic alkene, norbornene, mediates the reaction of 2H-azirines with aryl iodides under palladium catalysis to provide indole or polycyclic dihydroimidazole heterocycles.

Reaction of vinyl triflates of α-keto esters with primary amines: Efficient synthesis of aziridine carboxylates

Vinyl triflates of α-keto esters react smoothly with primary amines to provide aziridine carboxylates in good yields. In all cases, little or no stereoselectivity was observed. A mechanistic study has shown that aziridine carboxylates are strictly formed

Regiospecific reductive cleavage of the C(2)-N bond of aziridines substituted with an electron acceptor mediated by Mg/MeOH

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