127152-64-1

Basic information

• Product Name: 5-(4-BROMO-BENZYL)-2H-TETRAZOLE
• Synonyms: BUTTPARK 49\01-78;5-(4-BROMO-BENZYL)-2H-TETRAZOLE;1H-TETRAZOLE, 5-[(4-BROMOPHENYL)METHYL]-
• CAS NO: 127152-64-1
• Molecular Formula: C₈H₇BrN₄
• Molecular Weight: 239.07
• EINECS: 604-604-1
• Mol File: 127152-64-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-BROMO-BENZYL)-2H-TETRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-BROMO-BENZYL)-2H-TETRAZOLE(127152-64-1)
• EPA Substance Registry System: 5-(4-BROMO-BENZYL)-2H-TETRAZOLE(127152-64-1)

Safety Data

• Hazardous Substances Data: 127152-64-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-(4-BROMO-BENZYL)-2H-TETRAZOLE is used as a key intermediate in the development of new antihypertensive and anti-inflammatory medications, contributing to the advancement of treatments for cardiovascular and inflammatory diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 5-(4-BROMO-BENZYL)-2H-TETRAZOLE serves as a versatile building block for the synthesis of various heterocyclic compounds, expanding the scope of chemical structures and potential applications in different industries.
Used in Biochemical Studies:
Due to its stability and relatively low toxicity, 5-(4-BROMO-BENZYL)-2H-TETRAZOLE is utilized in biochemical studies to investigate the interactions and mechanisms of action of various biologically active compounds, furthering our understanding of their therapeutic potential.

Upstream product

• 16532-79-9 4-Bromophenylacetonitrile 

Downstream Products

• 127152-65-2 5-<(4-bromophenyl)methyl>-2-(1,1-dimethylethyl)-2H-tetrazole 
• 1620085-17-7 (R)-5-((4’-(2-(2-methylpyrrolidin-1-yl)ethyl)biphenyl-4-yl)-methyl)-1H-tetrazole 
• 127152-85-6 (+/-)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>-α-aminobenzenepropanoic acid phenylmethyl ester p-toluenesulfonate 
• 127152-72-1 (+/-)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>-α-<(diphenylmethylene)amino>benzenepropanoic acid phenylmethyl ester 
• 127152-91-4 (+/-)-α-(acetylamino)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzenepropanoic acid phenylmethyl ester 
• 127152-97-0 (+/-)-α-(acetylamino)-4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzenepropanoic acid 
• 127152-66-3 4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzoic acid 
• 127152-68-5 5-<<4-(bromomethyl)phenyl>methyl>-2-(1,1-dimethylethyl)-2H-tetrazole 
• 127152-67-4 4-<<2-(1,1-dimethylethyl)-2H-tetrazol-5-yl>methyl>benzenemethanol 

Relevant articles and documents

Synthesis, characterization and catalytic activity of graphene oxide/ZnO nanocomposites

This paper reports on the synthesis and use of graphene oxide/ZnO nanocomposite as a heterogeneous catalyst for the synthesis of various tetrazoles. The catalyst was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and UV-vis spectroscopy. This method has the advantages of high yields, elimination of homogeneous catalysts or corrosive acids, simple methodology and easy work up. Another important factor is the stability and recyclability of the catalyst under the reaction conditions used. This heterogeneous catalyst shows no significant loss of activity in the recycling experiments. the Partner Organisations 2014.

Green synthesis of 5-substituted-1H-1,2,3,4-tetrazoles and 1-sustituted-1H-1,2,3,4-tetrazoles via [3+2] cycloaddition by reusable immobilized AlCl3on -Al2O3

We report the effectiveness of the surface modified γ-Al2O3which is reusable, efficient, catalytic, safe and environmentally acceptable procedure for the conversion of both alkyl and aryl nitriles into the corresponding 5-substituted-1H-1,2,3,4-tetrazoles via [3+2] cycloaddition with sodium azide in excellent yields at mild reaction conditions (50 ° C). The catalyst also afforded 1-substituted-1H-1,2,3,4-tetrazoles by the reaction of amines, sodium azide and triethyl orthoformate. The catalyst could be recycled and was reused eleven runs without losing its activity.

Analogs of tyrosine sulfate or tyrosine phosphate containing peptides

Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount

Carboxylic Acids and Tetrazoles as Isosteric Replacements for Sulfate in Cholecystokinin Analogues

A series of analogues of the satiely-inducing peptide cholecystokinin (CCK-8) was prepared in which the sulfated tyrosine required for activation of peripheral receptors was replaced with a carboxy(alkyl)- or tetrazolyl(alkyl)-phenylalanine to investigate whether an organic acid could serve the role of the sulfate group at the receptor.The necessary intermediates were prepared by previously reported procedures or by alkylation of carboxy(alkyl)- or tetrazolyl(alkyl)phenylmethyl bromides with a glycine-derived anion followed by protecting-group manipulations, and these were incorporated into derivatives of acetyl-CCK-7 using solid-phase synthesis.Peptide analogues were evaluated in a CCK-binding assay for affinity for either peripheral (CCK-B) receptors using homogenated rat pancreatic membranes as the receptor source or for central (CCK-B) receptors using bovine striatum as the receptor source.They were further evaluated for effects on food intake in rats after intraperitoneal (ip) injection.A number of the compounds reported are active in the CCK-A receptor binding assay although less potent than acetyl-CCK-7 and decrease food intake with comparable potency to acetyl-CCK-7.In a meal feeding model designed to assess appetite suppressant activity, acetyl-CCK-7 has an ED50 of 7 nmol/kg ip, while the ED50s of Ac-Phe(4-CH2CO2H)-Met-Gly-Trp-Met-Asp-Phe-NH2 (28) and Ac-Phe-Met-Gly-Trp-Met-Asp-Phe-NH2 (34) were 9 and 11 nmol/kg ip, respectively.An analogue of 28 lacking the N-terminal acetamido group, 3-propanoyl-Met-Gly-Trp-Met-Asp-Phe-NH2 (50), was also active in the meal feeding assay with an ED50 of 3 nmol/kg ip.Its anorexic effect was blocked by simultaneous administration of the CCK-A receptor antagonist MK 329, indicating that the observed anorexic activity is mediated by CCK-A receptors.We conclude from this work that the requirement for a negative charge at the CCK-A receptor provided in the natural substrate by a sulfate group can be satisfied by organic acids.