127378-26-1Relevant articles and documents
Discovery of low-molecular-weight ligands for the AF6 PDZ domain
Joshi, Mangesh,Vargas, Carolyn,Boisguerin, Prisca,Diehl, Annette,Krause, Gerd,Schmieder, Peter,Moelling, Karin,Hagen, Volker,Schade, Markus,Oschkinat, Hartmut
, p. 3790 - 3795 (2006)
In the groove: The "drugability" of protein-protein interaction domains is still a matter of debate. The 3D structure of a complex of a small organic ligand and the AF6 PDZ domain revealed the creation of a binding pocket by the ligand (see picture). The
CHARGE CONTROLLING AGENT AND TONER USING SAME
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Page/Page column 24, (2013/02/27)
The present invention provides a charge control agent containing, as an active substance(s), one or two or more rhodanine compounds represented by the following formula (1). where R1 represents a hydrogen atom, etc.; R2 represents a hydrogen atom, a linea
Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2
Russell, Angela J.,Westwood, Isaac M.,Crawford, Matthew H.J.,Robinson, James,Kawamura, Akane,Redfield, Christina,Laurieri, Nicola,Lowe, Edward D.,Davies, Stephen G.,Sim, Edith
experimental part, p. 905 - 918 (2009/09/25)
The identification, synthesis and evaluation of a series of rhodanine and thiazolidin-2,4-dione derivatives as selective inhibitors of human arylamine N-acetyltransferase 1 and mouse arylamine N-acetyltransferase 2 is described. The most potent inhibitors
COMPOUNDS USEFUL AS HYPOGLYCEMIC AGENTS AND FOR TREATING ALZHEIMER'S DISEASE
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, (2008/06/13)
Provided are methods for treating hyperglycemia and Alzheimer's disease utilizing certain rhodanine derivatives. Certain of the rhodanine derivatives utilized in the instant methods are novel and, accordingly, such compounds and pharmaceutical formulation