127588-57-2Relevant articles and documents
N2S2 tetradentate ligands for soft cationic species: preparation of new ligands of potential interest in nuclear medicine
Charbonnel-Jobic, Gaelle,Guemas, Jean-Pierre,Adelaere, Bruno,Parrain, Jean-Luc,Quintard, Jean-Paul
, p. 624 - 636 (2007/10/02)
The synthesis of N2S2 tetradentate ligands of the bis-(enaminothioester) type was carried out starting from 3-(methylthio)-3H-1,2-dithiolylium iodides and diamines.The title compounds, which are potential ligands for soft cationic species, can be obtained from 1,3-diaminopropan-2-ol and subsequently modified into the dissymmetrical succinic acid ester of the ligand and N-hydroxysuccinimide.The appendage of such a linking group on the chelating structure should allow further grafting to monoclonal antibodies in view of potential applications in nuclear medicine. 3H-1,2-dithiole-3-thione / 1,3-diaminopropan-2-ol / bis-(enaminothioester) / N2S2 tetradentate ligand / N-hydroxysuccinimidyl ester