127946-00-3Relevant articles and documents
Potent and orally bioavailable 8-bicyclo[2.2.2]octylxanthines as adenosine A1 receptor antagonists
Kiesman, William F.,Zhao, Jin,Conlon, Patrick R.,Dowling, James E.,Petter, Russell C.,Lutterodt, Frank,Jin, Xiaowei,Smits, Glenn,Fure, Mary,Jayaraj, Andrew,Kim, John,Sullivan, Gail,Linden, Joel
, p. 7119 - 7131 (2008/04/18)
In the search for a selective adenosine A1 receptor antagonist with greater aqueous solubility than the compounds currently in clinical trials as diuretics, a series of 1,4-substituted 8-cyclohexyl and 8-bicyclo-[2.2.2] octylxanthines were inve
