128495-46-5

Basic information

• Product Name: 4-FLUORO-3-METHOXYBENZALDEHYDE
• Synonyms: 4-FLUORO-M-ANISALDEHYDE;4-FLUORO-3-METHOXYBENZALDEHYDE;3-METHOXY-4-FLUOROBENZALDEHYDE;4-Fluoro-3-methoxybenzaldehyde 97%;4-Fluoro-3-methoxybenzaldehyde97%;4-Fluoro-3-methoxybenzaldehyde ,98%;2-Fluoro-5-formylanisole, 4-Fluoro-m-anisaldehyde;4-Fluoro-M-anisaldehyde, 96.0%(GC)
• CAS NO: 128495-46-5
• Molecular Formula: C₈H₇FO₂
• Molecular Weight: 154.14
• EINECS: 1806241-263-5
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Benzaldehyde;Adehydes, Acetals & Ketones;Anisoles, Alkyloxy Compounds & Phenylacetates;Fluorine Compounds;Aldehydes;C8;Carbonyl Compounds;Aryl Fluorinated Building Blocks;Building Blocks;C7-C8;Carbonyl Compounds;Chemical Synthesis;Fluorinated Building Blocks;Organic Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Fluorine series
• Mol File: 128495-46-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 58-62 °C(lit.)
• Boiling Point: 246.3 °C at 760 mmHg
• Flash Point: 99.8 °C
• Appearance: white solid
• Density: 1.192 g/cm³
• Vapor Pressure: 0.0273mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Sensitive: Air Sensitive
• BRN: 5178063
• CAS DataBase Reference: 4-FLUORO-3-METHOXYBENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO-3-METHOXYBENZALDEHYDE(128495-46-5)
• EPA Substance Registry System: 4-FLUORO-3-METHOXYBENZALDEHYDE(128495-46-5)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-36
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 128495-46-5(Hazardous Substances Data)

Usage

Chemical Properties

White to yellow to tan powder or crystal or crystalline powder

Synthesis Reference(s)

Journal of Medicinal Chemistry, 33, p. 2408, 1990 DOI: 10.1021/jm00171a014

InChI:InChI=1/C8H7FO2/c1-11-8-4-6(5-10)2-3-7(8)9/h2-5H,1H3

Upstream product

• 63762-79-8 2-fluoro-5-methylphenol 
• 68-12-2 N,N-dimethyl-formamide 
• 103291-07-2 4-bromo-1-fluoro-2-methoxy-benzene 
• 194018-68-3 vanillin triflate 
• 74385-37-8 methyl 4-fluoro-3-methoxy-benzoate 
• 452-84-6 3-amino-4-fluorotoluene 
• 63762-78-7 1-fluoro-2-methoxy-4-methylbenzene 
• 82846-18-2 4?fluoro-3-methoxybenzoic acid 
• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 

Downstream Products

• 870837-24-4 4-(4-bromo-1H-imidazol-1-yl)-3-methoxybenzaldehyde 
• 103438-91-1 3-benzyloxy-4-fluorobenzaldehyde 
• 347176-70-9 3-benzyloxy-4-N,N-dimethylaminobenzaldehyde 
• 128495-45-4 (4-fluoro-3-methoxy-phenyl)methanol 
• 433920-87-7 3-methoxy-4-(1H-pyrazol-1-yl)benzaldehyde 
• 902767-90-2 (4-(4-ethylpiperazinyl)-3-methoxyphenyl)formaldehyde 
• 867070-33-5 9-(4-fluoro-3-methoxyphenyl)-6,9-dihydro[1,3]dioxolo[4,5-g]furo[3,4-b]quinolin-8(5H)-one 
• 205187-83-3 4,4-N,N'-dimethylamino-3-methoxybenzaldehyde 
• 1208237-25-5 C₉H₉FN₂O 
• 1415609-45-8 5-chloro-3-(3-methoxy-4-(methylsulfonyl)benzylidene)indolin-2-one 
• 1415609-52-7 3-methoxy-4-(methylsulfonyl)benzaldehyde 
• 1438487-73-0 (5-(4-fluoro-3-methoxyphenyl)-2-(2-nitrophenyl)-2H-1,2,3-triazol-4-yl)(4-fluorophenyl)methanone 

Relevant articles and documents

Preparation method of 3-methoxy-4-fluorobenzaldehyde

The invention discloses a preparation method of 3-methoxy-4-fluorobenzaldehyde. The method comprises the following steps: (1) reacting 3,4-difluorobromobenzene serving as a starting raw material withsodium methoxide to generate a compound III; and (2) reacting the compound III with magnesium to generate a Grignard reagent, and reacting under the condition of N,N-dimethylformamide to generate a compound I, wherein the obtained product is the 3-methoxy-4-fluorobenzaldehyde. The preparation method provided by the invention is higher in yield.

COMPOUND OF CAMPTOTHECIN AND PREPARATION AND USE THEREOF

The present disclosure relates to a compound of formula I, a pharmaceutical composition thereof and the use thereof as an anti-tumor drug.

MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN

The present invention relates to use of a compound of formula (I), (Ia), or (Ib), wherein A, B, Z, R1and R2 have the meanings given in the specification, as a medicament for the treatment of a number of pain conditions, particularly chronic or nociceptive