128753-68-4Relevant articles and documents
Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-L-rhamnose triacetate upon phosphitylation
Sun, Qi,Yang, Qingkun,Gong, Shanshan,Fu, Quanlei,Xiao, Qiang
, p. 6778 - 6787 (2013/10/22)
A novel and efficient strategy for the synthesis of phosphoramidon and its β anomer has been developed by manipulating the anomerization of α-l-rhamnose triacetate upon phosphitylation. The experimental results suggest that proton transfer, bond rotation, and N atom are the key factors for the anomerization. The determined Ki and Kd values establish that phosphoramidon prepared by this method possesses excellent biological activity, and indicate that the contacts of rhamnose moiety with the enzyme have limited contribution to the binding.
Synthesis of a new fluorogenic substrate for the continuous assay of mammalian phosphoinositide-specific phospholipase C
Rukavishnikov, Aleksey V.,Zaikova, Tatiana O.,Birrell, G. Bruce,Keana, John F. W.,Griffith, O. Hayes
, p. 1133 - 1136 (2007/10/03)
The synthesis of a fluorogenic substrate for mammalian phosphoinositide- specific phospholipase C is described. The substrate, based on the widely used fluorescein molecule, is a water-soluble substrate analog of phosphatidylinositol-4-phosphate. The fluorogenic substrate 2 is shown to be a sensitive substrate for human PI-PLC-δ1 in a continuous assay.
Tethered IP3. Synthesis and biochemical applications of the 1-O-(3-aminopropyl) ester of inositol 1,4,5-trisphosphate
Prestwich, Glenn D.,Marecek, James F.,Mourey, Robert J.,Theibert, Anne B.,Ferris, Christopher D.,Danoff, Sonye K.,Snyder, Solomon H.
, p. 1822 - 1825 (2007/10/02)
A phosphodiester analogue of the second messenger Ins(1,4,5)P3 has been synthesized and used to prepare a novel photoaffinity label and a selective bioaffinity matrix. A selectively protected inositol precursor was first converted by phosphite
