1289643-62-4Relevant articles and documents
Metabolism of diltiazem: A short efficient synthesis of N, N -didesmethyldiltiazem - An important product of N-demethylation
Babu, Kantipudi N.,Kunze, Kent L.,Nelson, Wendel L.
experimental part, p. 553 - 554 (2011/04/15)
An important product of CYP-450 catalyzed N-demethylation of diltiazem is the primary amine didesmethyldiltiazem. An efficient two-step synthesis of this metabolite was developed via N-alkylation of (2S,3S)-cis-3-acetoxy-2,3-dihydro- 2-(4-methoxy-phenyl)-