129144-90-7

Basic information

• Product Name: 2-Butenoic acid, 2-methyl-4-(triphenylphosphoranylidene)-, methyl ester, (E)-
• CAS NO: 129144-90-7
• Molecular Formula: C24H23O2P
• Molecular Weight: 374.419
• Mol File: 129144-90-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 2-methyl-4-(triphenylphosphoranylidene)-, methyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 2-methyl-4-(triphenylphosphoranylidene)-, methyl ester, (E)-(129144-90-7)
• EPA Substance Registry System: 2-Butenoic acid, 2-methyl-4-(triphenylphosphoranylidene)-, methyl ester, (E)-(129144-90-7)

Safety Data

• Hazardous Substances Data: 129144-90-7(Hazardous Substances Data)

Upstream product

• 80-59-1 Tiglic acid 
• 6622-76-0 methyl (E)-2-methyl-2-butenoate 
• 99968-60-2 methyl (E)-4-bromo-2-methylbut-2-enoate 
• 121666-37-3 <3-(Methoxycarbonyl)-2-butenyl>triphenylphosphoniumbromid 

Downstream Products

• 122001-44-9 methyl 2-methyl-7-phenyl-2,4,6-heptatrienoate 
• 5892-54-6 Crocetindimethylester 
• 64603-92-5 sodium (2E,4E,6E,8E,10E,12E,14E)-2,6,11,15-tetramethylhexadeca-2,4,6,8,10,12,14-heptaenedioate 
• 27876-94-4 crocetin 
• 477200-83-2 (2E,4E)-(R)-6-{(2R,4R,6S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-6-phenylsulfanyl-tetrahydro-pyran-2-yl}-2-methyl-hepta-2,4-dienoic acid methyl ester 
• 197771-13-4 (2E,4E)-(R)-6-((2R,4R,6S)-4-Cyanomethyl-6-phenylsulfanyl-tetrahydro-pyran-2-yl)-2-methyl-hepta-2,4-dienoic acid methyl ester 
• 129144-95-2 (2E,4E,6Z)-6-(tert-Butyl-diphenyl-silanyloxymethyl)-2-methyl-octa-2,4,6-trienoic acid methyl ester 

Relevant articles and documents

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Characterization of the Saffron Derivative Crocetin as an Inhibitor of Human Lactate Dehydrogenase 5 in the Antiglycolytic Approach against Cancer

Inhibition of lactate dehydrogenase (LDH) represents an innovative approach to tackle cancer because this peculiar glycolytic metabolism is characteristic of most invasive tumor cells. An investigation into the biological properties of saffron extracts led to the discover of their LDH-inhibition properties. In particular, the most important saffron components, crocetin, was found to inhibit LDH (IC50 = 54.9 ± 4.7 μM). This carotenoid was independently produced by chemical synthesis, and its LDH-inhibition properties manifested via its antiproliferative activity against two glycolytic cancer cell lines (A549 and HeLa, IC50 = 114.0 ± 8.0 and 113.0 ± 11.1 μM, respectively). The results described in this article suggest that saffron may be a helpful alimentary component in the prevention of cancer that potentially contributes to the efficacy of approved cancer therapies.

Bipolar trans carotenoid salts and their uses

The invention relates to trans carotenoid salt compounds, methods for making them, methods for solubilizing them and uses thereof. These compounds are useful in improving diffusivity of oxygen between red blood cells and body tissues in mammals including humans.